TY - JOUR
T1 - Suppression of the P50 evoked response and neuregulin 1-induced AKT phosphorylation in first-episode schizophrenia
AU - Kéri, Szabolcs
AU - Beniczky, Sándor
AU - Kelemen, Oguz
PY - 2010/4
Y1 - 2010/4
N2 - OBJECTIVE: Diminished suppression of the P50 auditory evoked potential is a widely used sensory gating phenotype in the molecular genetic studies of schizophrenia. The aim of this study was to explore the relationship between this phenotype and neuregulin 1-related intracellular signaling processes.METHOD: The P50 evoked potential was recorded in 30 first-episode, never-medicated patients with schizophrenia and in 30 healthy comparison volunteers. Neuregulin 1-induced activation of the phosphoinositide 3'-kinase (PI3K)/protein kinase B (AKT)/glycogen synthase kinase-3beta system was characterized by the measurement of the phosphorylated AKT to total AKT ratio in peripheral B lymphoblasts.RESULTS: Relative to comparison subjects, patients with first-episode schizophrenia displayed diminished P50 suppression and decreased neuregulin 1-induced AKT phosphorylation. There was a significant relationship between P50 suppression and AKT phosphorylation.CONCLUSION: Decreased neuregulin 1-induced activation of the PI3K/AKT system is associated with impaired sensory gating in first-episode schizophrenia.
AB - OBJECTIVE: Diminished suppression of the P50 auditory evoked potential is a widely used sensory gating phenotype in the molecular genetic studies of schizophrenia. The aim of this study was to explore the relationship between this phenotype and neuregulin 1-related intracellular signaling processes.METHOD: The P50 evoked potential was recorded in 30 first-episode, never-medicated patients with schizophrenia and in 30 healthy comparison volunteers. Neuregulin 1-induced activation of the phosphoinositide 3'-kinase (PI3K)/protein kinase B (AKT)/glycogen synthase kinase-3beta system was characterized by the measurement of the phosphorylated AKT to total AKT ratio in peripheral B lymphoblasts.RESULTS: Relative to comparison subjects, patients with first-episode schizophrenia displayed diminished P50 suppression and decreased neuregulin 1-induced AKT phosphorylation. There was a significant relationship between P50 suppression and AKT phosphorylation.CONCLUSION: Decreased neuregulin 1-induced activation of the PI3K/AKT system is associated with impaired sensory gating in first-episode schizophrenia.
KW - Adult
KW - Cognition Disorders/diagnosis
KW - Evoked Potentials, Auditory/drug effects
KW - Female
KW - Hippocampus/drug effects
KW - Humans
KW - Male
KW - Neuregulin-1/pharmacology
KW - Nucleus Accumbens/drug effects
KW - Phosphorylation/drug effects
KW - Phosphotransferases/metabolism
KW - Proto-Oncogene Proteins c-akt/metabolism
KW - Schizophrenia/drug therapy
KW - Sensory Gating
KW - Severity of Illness Index
KW - Signal Transduction/drug effects
KW - Wechsler Scales
U2 - 10.1176/appi.ajp.2009.09050723
DO - 10.1176/appi.ajp.2009.09050723
M3 - Article
C2 - 20048019
SN - 0002-953X
VL - 167
SP - 444
EP - 450
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
IS - 4
ER -