Sumatriptan does not affect arteriovenous oxygen differences in jugular and cubital veins in normal human subjects

T. Wienecke, J. M. Hansen, J. Petersen, K. S. Olsen, M. Ashina, P. Tfelt-Hansen

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    Abstrakt

    Arteriovenous anastomoses (AVAs) may open up during migraine attacks. In studies with anaesthetized and bilaterally vagosympatectomized pigs, triptans reduce AVA blood flow and increase the arteriovenous O2 difference (AVDO2). To investigate whether subcutaneous sumatriptan 6 mg could induce changes in the AVDO2, we measured the AVDO2 in the external jugular vein in healthy subjects. We also measured the AVDO2 in the internal jugular and cubital veins. There were no changes in AVDO 2 after subcutaneous sumatriptan, probably because AVA blood flow is limited in humans with an intact sympathetic nervous system.

    OriginalsprogEngelsk
    Sider (fra-til)1081-1085
    Antal sider5
    TidsskriftCephalalgia
    Vol/bind28
    Udgave nummer10
    DOI
    StatusUdgivet - 1 okt. 2008

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