SUDEP - more attention to the heart? A narrative review on molecular autopsy in epilepsy

Guilherme L Fialho*, Peter Wolf, Roger Walz, Katia Lin*

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Abstract

Sudden unexpected death in epilepsy (SUDEP) has been identified as one of the most prevalent causes of mortality in epilepsy, and SUDEP has consequently become an important topic of research. The causes appear multifactorial, including epilepsy-induced cardiac arrest. Current understanding of autopsy negative sudden unexplained death (SUD) in general population and its relation to sudden arrhythmic death syndrome (SADS) could shed some light in SUDEP. Mutual attention to the findings of sudden death in cardiology and epilepsy are discussed here. We performed a narrative review on SUDEP, epilepsy and molecular/genetic autopsy in this population. A proposal of an extended terminology for SUDEP classification is discussed in light of recent issues related to molecular autopsy and genetics. The extended classification might be a step forward in research protocols and a tool for better understanding SUDEP.

OriginalsprogEngelsk
Sider (fra-til)103-106
Antal sider4
TidsskriftSeizure
Vol/bind87
Tidlig onlinedato15 mar. 2021
DOI
StatusUdgivet - apr. 2021

Bibliografisk note

Copyright © 2021 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

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