Stratum corneum damage and ex vivo porcine skin water absorption - A pilot study

C. Duch Lynggaard; D. Bang Knudsen; G. B.E. Jemec

doi:10.1159/000241298

Stratum corneum damage and ex vivo porcine skin water absorption - A pilot study

C. Duch Lynggaard^*, D. Bang Knudsen, G. B.E. Jemec

^*Corresponding author af dette arbejde

Dermatologisk Afdeling

Publikation: Bidrag til tidsskrift › Letter › Forskning › peer review

Abstract

A simple ex vivo screening technique would be of interest for mass screening of substances for potential barrier disruptive qualities. Ex vivo water absorption as a marker of skin barrier integrity was studied on pig ear skin. Skin water absorption was quantified by weighing and weight changes were found to reflect prehydration barrier damage. It is suggested that this simple model may be elaborated to provide a rapid, economical screening tool for potential skin irritants.

Originalsprog	Engelsk
Sider (fra-til)	295-298
Antal sider	4
Tidsskrift	Skin Pharmacology and Physiology
Vol/bind	22
Udgave nummer	6
DOI	https://doi.org/10.1159/000241298
Status	Udgivet - 1 nov. 2009

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abstract = "A simple ex vivo screening technique would be of interest for mass screening of substances for potential barrier disruptive qualities. Ex vivo water absorption as a marker of skin barrier integrity was studied on pig ear skin. Skin water absorption was quantified by weighing and weight changes were found to reflect prehydration barrier damage. It is suggested that this simple model may be elaborated to provide a rapid, economical screening tool for potential skin irritants.",

keywords = "Porcine skin, Skin irritants, Water absorption barrier damage",

author = "{Duch Lynggaard}, C. and {Bang Knudsen}, D. and Jemec, {G. B.E.}",

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AU - Duch Lynggaard, C.

AU - Bang Knudsen, D.

AU - Jemec, G. B.E.

PY - 2009/11/1

Y1 - 2009/11/1

N2 - A simple ex vivo screening technique would be of interest for mass screening of substances for potential barrier disruptive qualities. Ex vivo water absorption as a marker of skin barrier integrity was studied on pig ear skin. Skin water absorption was quantified by weighing and weight changes were found to reflect prehydration barrier damage. It is suggested that this simple model may be elaborated to provide a rapid, economical screening tool for potential skin irritants.

AB - A simple ex vivo screening technique would be of interest for mass screening of substances for potential barrier disruptive qualities. Ex vivo water absorption as a marker of skin barrier integrity was studied on pig ear skin. Skin water absorption was quantified by weighing and weight changes were found to reflect prehydration barrier damage. It is suggested that this simple model may be elaborated to provide a rapid, economical screening tool for potential skin irritants.

KW - Porcine skin

KW - Skin irritants

KW - Water absorption barrier damage

UR - http://www.scopus.com/inward/record.url?scp=70349420144&partnerID=8YFLogxK

U2 - 10.1159/000241298

DO - 10.1159/000241298

M3 - Letter

C2 - 19786822

AN - SCOPUS:70349420144

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VL - 22

SP - 295

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JO - Skin Pharmacology and Physiology

JF - Skin Pharmacology and Physiology

IS - 6

ER -

Stratum corneum damage and ex vivo porcine skin water absorption - A pilot study

Abstract

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