Status and challenges after one hundred years with von Willebrand disease

The most common inherited bleeding disorder, von Willebrand disease (vWD), has been known for 100 years. Still, it is believed that many patients with mild disease remain undiagnosed. Detection of the condition relies on structured bleeding and family history, as well as laboratory evaluation. The variable presentation of vWD challenges both patients and clinicians, and women are particularly prone to diagnostic delay despite greater exposure to bleeding symptoms. Increasing clinical awareness and earlier identification of undiagnosed individuals should be prioritised.