ST peak during primary percutaneous coronary intervention predicts final infarct size, left ventricular function, and clinical outcome

Jacob Lonborg, Henning Kelbæk, Lene Holmvang, Niels Vejlstrup, Erik Jorgensen, Steffen Helqvist, Kari Saunamäki, Nadia P. Dridi, Kiril Aleksov Ahtarovski, Christian Juhl Terkelsen, Hans Erik Botker, Won Yong Kim, Marek Treiman, Peter Clemmensen, Thomas Engstrom

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    Abstrakt

    Background and Purpose: One third of patients treated with primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction develop a secondary increase in electrocardiographic ST segment (ST peak) during reperfusion. The purpose was to determine the clinical importance of ST peak during primary PCI. Methods: A total of 363 patients with ST-elevation myocardial infarction were stratified to no ST peak or ST peak. Final infarct size and ejection fraction (EF) were assessed by cardiovascular magnetic resonance. Results: Patients with ST peak had a larger infarct size (14% vs 10%; P =.003) and lower EF (53% vs 57%; P =.022). Rates of cardiac mortality (8% vs 3%; P =.047) and cardiac events (cardiac mortality and admission for heart failure; 19% vs 10%; P =.018) were higher among patients with ST peak, but not all-cause mortality (8% vs 5%; P =.46). In a multivariable Cox regression analysis, ST peak remained significantly associated with cardiac events (adjusted hazard ratio, 2.03 [1.08-3.82]). Conclusion: ST peak during primary PCI is related to larger final infarct size, a reduced EF, and adverse cardiac clinical outcome.

    OriginalsprogEngelsk
    Sider (fra-til)708-716
    Antal sider9
    TidsskriftJournal of Electrocardiology
    Vol/bind45
    Udgave nummer6
    DOI
    StatusUdgivet - 1 nov. 2012

    Fingeraftryk Udforsk hvilke forskningsemner 'ST peak during primary percutaneous coronary intervention predicts final infarct size, left ventricular function, and clinical outcome' indeholder.

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