Specific prediction of mortality by oxidative stress-induced damage to RNA vs. DNA in humans

Anders Jorgensen*, Ivan Brandslund, Christina Ellervik, Trine Henriksen, Allan Weimann, Per Kragh Andersen, Henrik E Poulsen

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftArtikelForskningpeer review


Modifications of nucleic acids (DNA and RNA) from oxidative stress is a potential driver of aging per se and of mortality in age-associated medical disorders such as type 2 diabetes (T2D). In a human cohort, we found a strong prediction of all-cause mortality by a marker of systemic oxidation of RNA in patients with T2D (n = 2672) and in nondiabetic control subjects (n = 4079). The finding persisted after the adjustment of established modifiers of oxidative stress (including BMI, smoking, and glycated hemoglobin). In contrast, systemic levels of DNA damage from oxidation, which traditionally has been causally linked to both T2D and aging, failed to predict mortality. Strikingly, these findings were subsequently replicated in an independent general population study (n = 3649). The data demonstrate a specific importance of RNA damage from oxidation in T2D and general aging.

TidsskriftAging Cell
Udgave nummer6
Tidlig onlinedato15 maj 2023
StatusUdgivet - jun. 2023

Bibliografisk note

© 2023 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.


Udforsk hvilke forskningsemner 'Specific prediction of mortality by oxidative stress-induced damage to RNA vs. DNA in humans' indeholder.