Somatosensory evoked potentials correlate with genetics in Huntington's disease

Sándor Beniczky, Szabolcs Kéri, Andrea Antal, Katalin Jakab, Helga Nagy, György Benedek, Zoltán Janka, László Vécsei

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    Abstrakt

    Abnormalities of somatosensory evoked potentials (SEPs) have been reported in Huntington's disease, a neuropsychiatric disorder caused by the expansion of a CAG trinucleotide repeat. The aim of our study was to determine the relationship between these electrophysiological changes and the length of the nucleotide repeat. We found a striking correlation between the decrease in the early component amplitudes (N20 and N30) of the median nerve SEP and the repeat length, suggesting that these SEP alterations are indeed related to the genetically determined pathological process. The cortical components of the tibial nerve SEP exhibited a dramatic alteration in the patient group and were the only SEP changes found in the group of asymptomatic carriers of the mutation, being more sensitive than the median nerve SEPs.

    OriginalsprogEngelsk
    Sider (fra-til)2295-8
    Antal sider4
    TidsskriftNeuroReport
    Vol/bind13
    Udgave nummer17
    DOI
    StatusUdgivet - 3 dec. 2002

    Fingeraftryk Udforsk hvilke forskningsemner 'Somatosensory evoked potentials correlate with genetics in Huntington's disease' indeholder.

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