TY - JOUR
T1 - Smoking as a contributing factor for development of polycythemia vera and related neoplasms
AU - Hasselbalch, Hans Carl
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Smoking may be associated with accelerated erythropoiesis, leukocytosis and thrombocytosis, which are also hallmarks in patients with polycythemia vera, essential thrombocythemia and early stages of myelofibrosis (MPNs). The JAK-STAT and NF-κB signaling pathways are activated in both smokers and in patients with MPNs. Additionally, both share elevated levels of several proinflammatory cytokines, in vivo activation of leukocytes and platelets, endothelial dysfunction and increased systemic oxidative stress. Based upon experimental, epidemiological and clinical data it is herein argued and discussed, if smoking may be involved in MPN pathogenesis, considering most recent studies and reviews which are supportive of the concept that chronic inflammation with NF-κB activation and oxidative stress may have a major role - both as triggers but also as the driving force for clonal expansion in MPNs.
AB - Smoking may be associated with accelerated erythropoiesis, leukocytosis and thrombocytosis, which are also hallmarks in patients with polycythemia vera, essential thrombocythemia and early stages of myelofibrosis (MPNs). The JAK-STAT and NF-κB signaling pathways are activated in both smokers and in patients with MPNs. Additionally, both share elevated levels of several proinflammatory cytokines, in vivo activation of leukocytes and platelets, endothelial dysfunction and increased systemic oxidative stress. Based upon experimental, epidemiological and clinical data it is herein argued and discussed, if smoking may be involved in MPN pathogenesis, considering most recent studies and reviews which are supportive of the concept that chronic inflammation with NF-κB activation and oxidative stress may have a major role - both as triggers but also as the driving force for clonal expansion in MPNs.
KW - Atherosclerosis
KW - Chronic myelomonocytic stimulation
KW - Essential thrombocythemia
KW - IL-8
KW - JAK-STAT-signaling
KW - Myeloproliferative neoplasms MPNs
KW - NF-κB
KW - Polycythemia vera
KW - Primary myelofibrosis
KW - Smoking
KW - Thrombosis
UR - http://www.scopus.com/inward/record.url?scp=84955353963&partnerID=8YFLogxK
U2 - 10.1016/j.leukres.2015.09.002
DO - 10.1016/j.leukres.2015.09.002
M3 - Review
C2 - 26463040
AN - SCOPUS:84955353963
VL - 39
SP - 1137
EP - 1145
JO - Leukemia Research
JF - Leukemia Research
SN - 0145-2126
IS - 11
ER -