Sirolimus versus bare metal stent implantation in patients with total coronary occlusions. Subgroup analysis of the Stenting Coronary Arteries in Non-Stress/Benestent Disease (SCANDSTENT) Trial

Henning Kelbæk, Steffen Helqvist, Leif Thuesen, Lene Kløvgaard, Erik Jørgensen, Kari Saunamäki, Lars R. Krusell, Hans E. Bøtker, Thomas Engstrøm, Gunnar V.H. Jensen

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    Background: Coronary restenosis is more common in a total coronary occlusion (TCO) than other lesion types after implantation of bare metal stents (BMS). But whereas sirolimus-eluting stents (SES) have been shown to improve the outcomes in simple coronary artery lesions, data on their efficacy in complex coronary lesions are scarce. Methods: We enrolled 127 patients with coronary artery disease and a TCO ≥ 15 mm in length to have either SES or BMS implanted after successful recanalization. Outcome measures included the minimal lumen diameter, the late lumen loss, and angiographic restenosis (>50% diameter stenosis) at 6 months follow-up and the occurrence of target vessel failure during a 7-month period. Results: The patients were well matched in demographic and angiographic baseline characteristics, and 20% had diabetes. The reference vessel was 2.92 mm in mean, and the lesion length was 25.2 mm. At follow-up, patients who received SES had a minimal lumen diameter of 2.49 mm compared with 1.46 mm in those who received BMS (P = .015), 0% versus 38% developed restenosis (P < .001), lumen loss was -0.05 versus 0.99 mm (P < .001), and the target vessel failure rate 5% with SES versus 35% with BMS (P < .001). Stent thrombosis occurred in 1 patient in the BMS group. Conclusions: Implantation of SES is safe, and it markedly reduces angiographic restenosis and the occurrence of adverse events in patients with a TCO.

    OriginalsprogEngelsk
    Sider (fra-til)882-886
    Antal sider5
    TidsskriftAmerican Heart Journal
    Vol/bind152
    Udgave nummer5
    DOI
    StatusUdgivet - 1 nov. 2006

    Fingeraftryk

    Udforsk hvilke forskningsemner 'Sirolimus versus bare metal stent implantation in patients with total coronary occlusions. Subgroup analysis of the Stenting Coronary Arteries in Non-Stress/Benestent Disease (SCANDSTENT) Trial' indeholder.

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