TY - JOUR
T1 - Single and multiple time-point allergic sensitization during childhood and risk of asthma by age 13
AU - Schoos, Ann Marie Malby
AU - Jelding-Dannemand, Ea
AU - Stokholm, Jakob
AU - Bønnelykke, Klaus
AU - Bisgaard, Hans
AU - Chawes, Bo Lund
N1 - © 2019 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Background: The relationship between allergic sensitization during childhood and risk of developing asthma remains unclear. Objective: To analyze single time-point and temporal patterns of sensitization in childhood in relation to asthma at age 13. Methods: Specific IgE (sIgE) level and skin prick test (SPT) toward 22 food allergens and aeroallergens were assessed at 6, 18 months, 4, 6, and 13 years in children from the high-risk Copenhagen Prospective Studies on Asthma in Childhood2000 (COPSAC2000) mother-child cohort. We analyzed the association between single time-point monosensitization, polysensitization, and quantitative assessment of sensitization, that is, sum of all sIgE levels and SPT wheal sizes, against asthma at age 13. In addition, we analyzed the association between three temporal patterns of sensitization: (a) early-transient, (b) late-onset, and (c) persistent sensitization and asthma. Results: Polysensitization status measured by SPT or sIgE was at all single time-points associated with increased risk of asthma at age 13: OR range, SPT = 3.0-15.7, and sIgE = 2.6-15.7, respectively, whereas monosensitization status was inconsistently associated with asthma. Quantitative assessment of both sIgE and SPT results was associated with asthma at all single time-points: OR range, SPT = 1.3-3.6, and sIgE = 1.1-1.7. Persistent sensitization, but not early-transient or late-onset sensitization was associated with asthma by age 13: OR [95% CI], SPT = 8.9 [2.8-28.23], and sIgE = 2.9 [1.1-7.6], respectively. Conclusion: Sensitization to multiple allergens at single time-points, increasing sIgE levels and SPT wheal sizes, and persistent sensitization during childhood were associated with increased risk of asthma at age 13, suggesting the use of quantitative and repetitive sensitization measurements when assessing risk of developing asthma.
AB - Background: The relationship between allergic sensitization during childhood and risk of developing asthma remains unclear. Objective: To analyze single time-point and temporal patterns of sensitization in childhood in relation to asthma at age 13. Methods: Specific IgE (sIgE) level and skin prick test (SPT) toward 22 food allergens and aeroallergens were assessed at 6, 18 months, 4, 6, and 13 years in children from the high-risk Copenhagen Prospective Studies on Asthma in Childhood2000 (COPSAC2000) mother-child cohort. We analyzed the association between single time-point monosensitization, polysensitization, and quantitative assessment of sensitization, that is, sum of all sIgE levels and SPT wheal sizes, against asthma at age 13. In addition, we analyzed the association between three temporal patterns of sensitization: (a) early-transient, (b) late-onset, and (c) persistent sensitization and asthma. Results: Polysensitization status measured by SPT or sIgE was at all single time-points associated with increased risk of asthma at age 13: OR range, SPT = 3.0-15.7, and sIgE = 2.6-15.7, respectively, whereas monosensitization status was inconsistently associated with asthma. Quantitative assessment of both sIgE and SPT results was associated with asthma at all single time-points: OR range, SPT = 1.3-3.6, and sIgE = 1.1-1.7. Persistent sensitization, but not early-transient or late-onset sensitization was associated with asthma by age 13: OR [95% CI], SPT = 8.9 [2.8-28.23], and sIgE = 2.9 [1.1-7.6], respectively. Conclusion: Sensitization to multiple allergens at single time-points, increasing sIgE levels and SPT wheal sizes, and persistent sensitization during childhood were associated with increased risk of asthma at age 13, suggesting the use of quantitative and repetitive sensitization measurements when assessing risk of developing asthma.
KW - asthma
KW - children
KW - monosensitization
KW - patterns
KW - polysensitization
KW - sensitization
KW - skin prick test
KW - specific IgE
KW - Skin Tests
KW - Hypersensitivity/epidemiology
KW - Humans
KW - Child, Preschool
KW - Infant
KW - Male
KW - Risk
KW - Immunization/statistics & numerical data
KW - Denmark/epidemiology
KW - Adolescent
KW - Immunoglobulin E/blood
KW - Female
KW - Allergens/immunology
KW - Asthma/epidemiology
KW - Child
UR - http://www.scopus.com/inward/record.url?scp=85070770615&partnerID=8YFLogxK
U2 - 10.1111/pai.13109
DO - 10.1111/pai.13109
M3 - Article
C2 - 31299117
AN - SCOPUS:85070770615
SN - 0905-6157
VL - 30
SP - 716
EP - 723
JO - Pediatric Allergy and Immunology
JF - Pediatric Allergy and Immunology
IS - 7
ER -