TY - JOUR
T1 - Short-term oral treatment with the angiotensin II receptor antagonist losartan does not improve coronary vasomotor function in asymptomatic type 2 diabetes patients
AU - Kjær, Andreas
AU - Kristoffersen, Ulrik Sloth
AU - Tarnow, Lise
AU - Parving, Hans Henrik
AU - Hesse, Birger
PY - 2009/4/1
Y1 - 2009/4/1
N2 - Background: We have previously found that acute intravenous infusion of an ACE inhibitor normalized the reduced coronary vasomotor function in type 2 diabetes. The aim of the present study was to extend this investigation to an angiotensin II receptor blocker (ARB) administered orally in normotensive, asymptomatic type 2 diabetes patients without albuminuria. Results: Fourteen type 2 diabetes patients were included. Each patient had myocardial perfusion measured by PET at three occasions: at baseline, following 3 weeks of treatment with 50 mg/d and following another 3 weeks of treatment with 100 mg/d of losartan. Baseline myocardial perfusion was similar at all three sessions (0.89 ± 0.05, 0.90 ± 0.08 and 0.84 ± 0.05 mL/(min g) tissue, respectively). Likewise, maximal hyperaemic perfusion after i.v. dipyridamole (0.56 mg/kg bwt) was low but similar at the three sessions (2.01 ± 0.14, 2.05 ± 0.17 and 1.90 ± 0.20 mL/(min g) tissue, respectively). Myocardial perfusion reserve, i.e. maximal hyperaemic flow relative to baseline flow, was also low, but similar before and after treatment with losartan (2.36 ± 0.24, 2.44 ± 0.24 and 2.62 ± 0.42 mL/(min g) tissue, respectively). Conclusions: Oral treatment with an ARB did not normalize coronary vasomotor function in type 2 diabetes patients without cardiovascular disease.
AB - Background: We have previously found that acute intravenous infusion of an ACE inhibitor normalized the reduced coronary vasomotor function in type 2 diabetes. The aim of the present study was to extend this investigation to an angiotensin II receptor blocker (ARB) administered orally in normotensive, asymptomatic type 2 diabetes patients without albuminuria. Results: Fourteen type 2 diabetes patients were included. Each patient had myocardial perfusion measured by PET at three occasions: at baseline, following 3 weeks of treatment with 50 mg/d and following another 3 weeks of treatment with 100 mg/d of losartan. Baseline myocardial perfusion was similar at all three sessions (0.89 ± 0.05, 0.90 ± 0.08 and 0.84 ± 0.05 mL/(min g) tissue, respectively). Likewise, maximal hyperaemic perfusion after i.v. dipyridamole (0.56 mg/kg bwt) was low but similar at the three sessions (2.01 ± 0.14, 2.05 ± 0.17 and 1.90 ± 0.20 mL/(min g) tissue, respectively). Myocardial perfusion reserve, i.e. maximal hyperaemic flow relative to baseline flow, was also low, but similar before and after treatment with losartan (2.36 ± 0.24, 2.44 ± 0.24 and 2.62 ± 0.42 mL/(min g) tissue, respectively). Conclusions: Oral treatment with an ARB did not normalize coronary vasomotor function in type 2 diabetes patients without cardiovascular disease.
KW - Coronary arteries
KW - Positron emission tomography
KW - Type 2 diabetes
KW - Vasomotor function
UR - http://www.scopus.com/inward/record.url?scp=62049085401&partnerID=8YFLogxK
U2 - 10.1016/j.diabres.2009.01.010
DO - 10.1016/j.diabres.2009.01.010
M3 - Article
C2 - 19233497
AN - SCOPUS:62049085401
VL - 84
SP - 34
EP - 38
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
SN - 0168-8227
IS - 1
ER -