Shift work and incidence of dementia: A Danish Nurse Cohort study

Jeanette Therming Jørgensen; Johnni Hansen; Rudi G J Westendorp; Kirsten Nabe-Nielsen; Leslie Thomas Stayner; Mette Kildevaeld Simonsen; Zorana Jovanovic Andersen

doi:10.1002/alz.12126

Shift work and incidence of dementia: A Danish Nurse Cohort study

Jeanette Therming Jørgensen
, Johnni Hansen
, Rudi G J Westendorp
, Kirsten Nabe-Nielsen
, Leslie Thomas Stayner
, Mette Kildevaeld Simonsen
, Zorana Jovanovic Andersen

Center for Sundhedsforskning

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

INTRODUCTION: A few studies suggest that working night and rotating shifts increase the risk of dementia. We examined the association between shift work and the incidence of dementia in a cohort of female Danish nurses.

METHODS: We linked Danish Nurse Cohort participants, who reported work schedules (day, evening, night, rotating shifts) in 1993 and/or 1999 and their duration in 2009, to Danish registers to obtain information on dementia hospitalizations and prescription medication until November 2018.

RESULTS: Among 6048 nurses who reported work schedules in 1993 and 1999, nurses working night shifts ≥6 years had higher dementia incidence (hazard ratio: 2.43, 95% confidence interval: 1.39 to 4.23) than those working day shifts ≥6 years. Among 8059 nurses who reported shift work duration, nurses working night shifts ≥6 years had higher dementia incidence than those working night shifts <1 year (1.47, 1.06 to 2.06).

DISCUSSION: Persistent night shift work may increase the risk of dementia.

Originalsprog	Engelsk
Sider (fra-til)	1268-1279
Antal sider	12
Tidsskrift	Alzheimer's and Dementia
Vol/bind	16
Udgave nummer	9
Tidlig onlinedato	11 jul. 2020
DOI	https://doi.org/10.1002/alz.12126
Status	Udgivet - sep. 2020

Adgang til dokumentet

10.1002/alz.12126

Citationsformater

@article{6444078243794da9b6bc34d2a910a89d,

title = "Shift work and incidence of dementia: A Danish Nurse Cohort study",

abstract = "INTRODUCTION: A few studies suggest that working night and rotating shifts increase the risk of dementia. We examined the association between shift work and the incidence of dementia in a cohort of female Danish nurses.METHODS: We linked Danish Nurse Cohort participants, who reported work schedules (day, evening, night, rotating shifts) in 1993 and/or 1999 and their duration in 2009, to Danish registers to obtain information on dementia hospitalizations and prescription medication until November 2018.RESULTS: Among 6048 nurses who reported work schedules in 1993 and 1999, nurses working night shifts ≥6 years had higher dementia incidence (hazard ratio: 2.43, 95\% confidence interval: 1.39 to 4.23) than those working day shifts ≥6 years. Among 8059 nurses who reported shift work duration, nurses working night shifts ≥6 years had higher dementia incidence than those working night shifts <1 year (1.47, 1.06 to 2.06).DISCUSSION: Persistent night shift work may increase the risk of dementia.",

keywords = "Alzheimer's disease and dementia, cohort study, Danish Nurse Cohort, Denmark, neurodegenerative disease, night shift work, shift work, working time",

author = "J{\o}rgensen, \{Jeanette Therming\} and Johnni Hansen and Westendorp, \{Rudi G J\} and Kirsten Nabe-Nielsen and Stayner, \{Leslie Thomas\} and Simonsen, \{Mette Kildevaeld\} and Andersen, \{Zorana Jovanovic\}",

note = "{\textcopyright} 2020 the Alzheimer's Association.",

year = "2020",

month = sep,

doi = "10.1002/alz.12126",

language = "English",

volume = "16",

pages = "1268--1279",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "John Wiley \& Sons Inc.",

number = "9",

}

TY - JOUR

T1 - Shift work and incidence of dementia

T2 - A Danish Nurse Cohort study

AU - Jørgensen, Jeanette Therming

AU - Hansen, Johnni

AU - Westendorp, Rudi G J

AU - Nabe-Nielsen, Kirsten

AU - Stayner, Leslie Thomas

AU - Simonsen, Mette Kildevaeld

AU - Andersen, Zorana Jovanovic

PY - 2020/9

Y1 - 2020/9

N2 - INTRODUCTION: A few studies suggest that working night and rotating shifts increase the risk of dementia. We examined the association between shift work and the incidence of dementia in a cohort of female Danish nurses.METHODS: We linked Danish Nurse Cohort participants, who reported work schedules (day, evening, night, rotating shifts) in 1993 and/or 1999 and their duration in 2009, to Danish registers to obtain information on dementia hospitalizations and prescription medication until November 2018.RESULTS: Among 6048 nurses who reported work schedules in 1993 and 1999, nurses working night shifts ≥6 years had higher dementia incidence (hazard ratio: 2.43, 95% confidence interval: 1.39 to 4.23) than those working day shifts ≥6 years. Among 8059 nurses who reported shift work duration, nurses working night shifts ≥6 years had higher dementia incidence than those working night shifts <1 year (1.47, 1.06 to 2.06).DISCUSSION: Persistent night shift work may increase the risk of dementia.

AB - INTRODUCTION: A few studies suggest that working night and rotating shifts increase the risk of dementia. We examined the association between shift work and the incidence of dementia in a cohort of female Danish nurses.METHODS: We linked Danish Nurse Cohort participants, who reported work schedules (day, evening, night, rotating shifts) in 1993 and/or 1999 and their duration in 2009, to Danish registers to obtain information on dementia hospitalizations and prescription medication until November 2018.RESULTS: Among 6048 nurses who reported work schedules in 1993 and 1999, nurses working night shifts ≥6 years had higher dementia incidence (hazard ratio: 2.43, 95% confidence interval: 1.39 to 4.23) than those working day shifts ≥6 years. Among 8059 nurses who reported shift work duration, nurses working night shifts ≥6 years had higher dementia incidence than those working night shifts <1 year (1.47, 1.06 to 2.06).DISCUSSION: Persistent night shift work may increase the risk of dementia.

KW - Alzheimer's disease and dementia

KW - cohort study

KW - Danish Nurse Cohort

KW - Denmark

KW - neurodegenerative disease

KW - night shift work

KW - shift work

KW - working time

U2 - 10.1002/alz.12126

DO - 10.1002/alz.12126

M3 - Article

C2 - 32652788

SN - 1552-5260

VL - 16

SP - 1268

EP - 1279

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 9

ER -

Shift work and incidence of dementia: A Danish Nurse Cohort study

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater