Sex difference in leukocyte telomere length is ablated in opposite-sex co-twins

Athanase Benetos; Christine Dalgård; Carlos Labat; Jeremy D Kark; Simon Verhulst; Kaare Christensen; Masayuki Kimura; Kent Horvath; Kirsten Ohm Kyvik; Abraham Aviv

doi:10.1093/ije/dyu146

Sex difference in leukocyte telomere length is ablated in opposite-sex co-twins

Athanase Benetos, Christine Dalgård, Carlos Labat, Jeremy D Kark, Simon Verhulst, Kaare Christensen, Masayuki Kimura, Kent Horvath, Kirsten Ohm Kyvik, Abraham Aviv

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

BACKGROUND: In eutherian mammals and in humans, the female fetus may be masculinized while sharing the intra-uterine environment with a male fetus. Telomere length (TL), as expressed in leukocytes, is heritable and is longer in women than in men. The main determinant of leukocyte TL (LTL) is LTL at birth. However, LTL is modified by age-dependent attrition.METHODS: We studied LTL dynamics (LTL and its attrition) in adult same-sex (monozygotic, n = 268; dizygotic, n = 308) twins and opposite-sex (n = 144) twins. LTL was measured by Southern blots of the terminal restriction fragments.RESULTS: We observed that in same-sex (both monozygotic and dizygotic) twins, as reported in singletons, LTL was longer in females than in males [estimate ± standard error (SE):163 ± 63 bp, P

Originalsprog	Engelsk
Sider (fra-til)	1799-1805
Antal sider	7
Tidsskrift	International journal of epidemiology
Vol/bind	43
Udgave nummer	6
DOI	https://doi.org/10.1093/ije/dyu146
Status	Udgivet - 1 dec. 2014

Adgang til dokumentet

10.1093/ije/dyu146

Citationsformater

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title = "Sex difference in leukocyte telomere length is ablated in opposite-sex co-twins",

abstract = "BACKGROUND: In eutherian mammals and in humans, the female fetus may be masculinized while sharing the intra-uterine environment with a male fetus. Telomere length (TL), as expressed in leukocytes, is heritable and is longer in women than in men. The main determinant of leukocyte TL (LTL) is LTL at birth. However, LTL is modified by age-dependent attrition.METHODS: We studied LTL dynamics (LTL and its attrition) in adult same-sex (monozygotic, n = 268; dizygotic, n = 308) twins and opposite-sex (n = 144) twins. LTL was measured by Southern blots of the terminal restriction fragments.RESULTS: We observed that in same-sex (both monozygotic and dizygotic) twins, as reported in singletons, LTL was longer in females than in males [estimate ± standard error (SE):163 ± 63 bp, P ",

keywords = "Men, Sex, Telomeres, Twins, Women",

author = "Athanase Benetos and Christine Dalg{\aa}rd and Carlos Labat and Kark, \{Jeremy D\} and Simon Verhulst and Kaare Christensen and Masayuki Kimura and Kent Horvath and Kyvik, \{Kirsten Ohm\} and Abraham Aviv",

note = "{\textcopyright} The Author 2014. Published by Oxford University Press on behalf of the International Epidemiological Association.",

year = "2014",

month = dec,

day = "1",

doi = "10.1093/ije/dyu146",

language = "English",

volume = "43",

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journal = "International journal of epidemiology",

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TY - JOUR

T1 - Sex difference in leukocyte telomere length is ablated in opposite-sex co-twins

AU - Benetos, Athanase

AU - Dalgård, Christine

AU - Labat, Carlos

AU - Kark, Jeremy D

AU - Verhulst, Simon

AU - Christensen, Kaare

AU - Kimura, Masayuki

AU - Horvath, Kent

AU - Kyvik, Kirsten Ohm

AU - Aviv, Abraham

N1 - © The Author 2014. Published by Oxford University Press on behalf of the International Epidemiological Association.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - BACKGROUND: In eutherian mammals and in humans, the female fetus may be masculinized while sharing the intra-uterine environment with a male fetus. Telomere length (TL), as expressed in leukocytes, is heritable and is longer in women than in men. The main determinant of leukocyte TL (LTL) is LTL at birth. However, LTL is modified by age-dependent attrition.METHODS: We studied LTL dynamics (LTL and its attrition) in adult same-sex (monozygotic, n = 268; dizygotic, n = 308) twins and opposite-sex (n = 144) twins. LTL was measured by Southern blots of the terminal restriction fragments.RESULTS: We observed that in same-sex (both monozygotic and dizygotic) twins, as reported in singletons, LTL was longer in females than in males [estimate ± standard error (SE):163 ± 63 bp, P

AB - BACKGROUND: In eutherian mammals and in humans, the female fetus may be masculinized while sharing the intra-uterine environment with a male fetus. Telomere length (TL), as expressed in leukocytes, is heritable and is longer in women than in men. The main determinant of leukocyte TL (LTL) is LTL at birth. However, LTL is modified by age-dependent attrition.METHODS: We studied LTL dynamics (LTL and its attrition) in adult same-sex (monozygotic, n = 268; dizygotic, n = 308) twins and opposite-sex (n = 144) twins. LTL was measured by Southern blots of the terminal restriction fragments.RESULTS: We observed that in same-sex (both monozygotic and dizygotic) twins, as reported in singletons, LTL was longer in females than in males [estimate ± standard error (SE):163 ± 63 bp, P

KW - Men

KW - Sex

KW - Telomeres

KW - Twins

KW - Women

U2 - 10.1093/ije/dyu146

DO - 10.1093/ije/dyu146

M3 - Article

SN - 0300-5771

VL - 43

SP - 1799

EP - 1805

JO - International journal of epidemiology

JF - International journal of epidemiology

IS - 6

ER -