TY - JOUR
T1 - Serum YKL-40 and gestational diabetes – an observational cohort study
AU - Gybel-Brask, Dorte
AU - Johansen, Julia S.
AU - Christiansen, Ib J.
AU - Skibsted, Lillian
AU - Høgdall, Estrid V.S.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - To examine serum YKL-40 in women developing gestational diabetes mellitus (GDM). In the present large observational cohort study of 1179 pregnant women, we determined serum YKL-40 four times during pregnancy (at gestational age 12, 20, 25, and 32 weeks). Pregnancy outcome was obtained from medical records. Sixty-eight women (5.8%) developed GDM. Serum YKL-40 increased from gestational age (GA) 12 weeks and the following weeks in the women who developed GDM and was independent of BMI, parity, and maternal age (OR = 2.69, 95% CI: 1.45–5.00, p = 0.002). No association was found between serum YKL-40 and the oral glucose tolerance test results. In conclusion, YKL-40 significantly increased in pregnant women with GDM compared with women without GDM, probably reflecting the low-grade inflammation of GDM. However, we did not find an association between serum concentrations of YKL-40 in early pregnancy and the development of GDM and thus we conclude that YKL-40 alone is not usable as a biomarker for early prediction of GDM.
AB - To examine serum YKL-40 in women developing gestational diabetes mellitus (GDM). In the present large observational cohort study of 1179 pregnant women, we determined serum YKL-40 four times during pregnancy (at gestational age 12, 20, 25, and 32 weeks). Pregnancy outcome was obtained from medical records. Sixty-eight women (5.8%) developed GDM. Serum YKL-40 increased from gestational age (GA) 12 weeks and the following weeks in the women who developed GDM and was independent of BMI, parity, and maternal age (OR = 2.69, 95% CI: 1.45–5.00, p = 0.002). No association was found between serum YKL-40 and the oral glucose tolerance test results. In conclusion, YKL-40 significantly increased in pregnant women with GDM compared with women without GDM, probably reflecting the low-grade inflammation of GDM. However, we did not find an association between serum concentrations of YKL-40 in early pregnancy and the development of GDM and thus we conclude that YKL-40 alone is not usable as a biomarker for early prediction of GDM.
KW - biomarker
KW - gestational diabetes mellitus
KW - Pregnancy
KW - YKL-40
UR - http://www.scopus.com/inward/record.url?scp=84983412613&partnerID=8YFLogxK
U2 - 10.1111/apm.12573
DO - 10.1111/apm.12573
M3 - Article
C2 - 27457220
AN - SCOPUS:84983412613
VL - 124
SP - 770
EP - 775
JO - APMIS
JF - APMIS
SN - 0903-4641
IS - 9
ER -