Serum myoglobin for the early non-invasive detection of coronary reperfusion in patients with acute myocardial infarction

The ideal non-invasive method for detecting coronary reperfusion has not yet been established. In 63 patients with acute myocardial infarction, serum myoglobin and creatine kinase-MB were measured every 15 min. Thrombolytic treatment was given (n= 52) and acute coronary angiography showed a patent infarct-related artery in 49 patients while 14 patients had no coronary reperfusion. Median time to peak serum myoglobin was shorter (reperfusion group 178 min vs no reperfusion group 480 min, P<0.0001) than time to peak serum creatine kinase-MB (reperfusion group 550min vs no reperfusion group 1080min, P<0.0001), P<0.0001. Myoglobin appearance rate, calculated as the concentration at 2h divided by baseline values (Mb₂/Mb₀) was highest in the reperfusion group (4.0 vs 1.6), P<0.001. An earlier proposed index, Mb₂/Mb₀ >2.4 for identification of reperfusion 2 h after thrombolytic therapy, showed predictive values of positive and negative tests of 0.94 and 0.44, respectively. Combining this index with signs of medium to larger infarct size (Mb, >200 μg. I^-1) increased the predictive value of the negative test to 1.00. In patients with signs of minor infarcts (Mb, >200 μg. I^-1) the predictive values of positive and negative tests were 0.94 and 0.79, respectively, 5 h after onset of thrombolytic therapy. An early rise and a peak in serum myoglobin values seems to be a reliable and simple non-invasive indicator of successful and unsuccessful reperfusion therapy.