Serum-kreatinkinase isoenzym-MB og -myoglobin hos patienter med akut myokardieinfarkt og koronar reperfusion.

B. Jurlander*, P. M. Clemmensen, E. M. Ohman, G. S. Wagner, P. Grande

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    Thrombolytic therapy in patients with acute myocardial infarction (AMI) changes the time-concentration curve of serum creatine kinase isoenzyme MB (CK-MB) and serum myoglobin. In this study, 60 AMI patients received thrombolytic therapy and acute coronary arteriography, or conservative treatment. Group one (n = 32) demonstrated a patent infarct-related artery after intravenous thrombolytic therapy; group two (n = 17) had an initially occluded coronary artery which became patent during catheterisation; group three (n = 11) did not receive thrombolytic therapy. Frequent serum CK-MB and myoglobin measurements showed that patients with acute coronary reperfusion had a rapid increase, an earlier peak value and less total release of both CK-MB and myoglobin to blood compared to AMI patients treated conservatively. The changes in serum myoglobin compared to CK-MB demonstrated an even more rapid, more uniform, and relatively greater increase. Measurements of serum myoglobin may be a useful non-invasive method for evaluation of thrombolytic therapy in AMI patients.

    Bidragets oversatte titelSerum creatine kinase isoenzyme MB and myoglobin in patients with acute myocardial infarction and coronary reperfusion
    OriginalsprogDansk
    Sider (fra-til)2682-2686
    Antal sider5
    TidsskriftUgeskrift for laeger
    Vol/bind154
    Udgave nummer39
    StatusUdgivet - 21 sep. 1992

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