Self-assessed health status and associated mortality in endocarditis: secondary findings from the POET trial

Johan S Bundgaard; Kasper Iversen; Mia Pries-Heje; Nikolaj Ihlemann; Sabine U Gill; Trine Madsen; Hanne Elming; Jonas A Povlsen; Niels E Bruun; Dan E Høfsten; Kurt Fuursted; Jens J Christensen; Martin Schultz; Flemming Rosenvinge; Jannik Helweg-Larsen; Lars Køber; Christian Torp-Pedersen; Emil L Fosbøl; Niels Tønder; Claus Moser; Henning Bundgaard; Ulrik M Mogensen

doi:10.1007/s11136-022-03126-x

Self-assessed health status and associated mortality in endocarditis: secondary findings from the POET trial

Johan S Bundgaard^*, Kasper Iversen, Mia Pries-Heje, Nikolaj Ihlemann, Sabine U Gill, Trine Madsen, Hanne Elming, Jonas A Povlsen, Niels E Bruun, Dan E Høfsten, Kurt Fuursted, Jens J Christensen, Martin Schultz, Flemming Rosenvinge, Jannik Helweg-Larsen, Lars Køber, Christian Torp-Pedersen, Emil L Fosbøl, Niels Tønder, Claus MoserHenning Bundgaard, Ulrik M Mogensen

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

PURPOSE: Self-assessed poor health status is associated with increased risk of mortality in several cardiovascular conditions, but has not been investigated in patients with endocarditis. We examined health status and mortality in patients with endocarditis.

METHODS: This is a re-specified substudy of the randomized POET endocarditis trial, which included 400 patients. Patients completed the single-question self-assessed health status from the Short-Form 36 questionnaire at time of randomization and were categorized as having poor or non-poor (excellent/very good, good, or fair) health status. Self-assessed health status and all-cause mortality were examined by a Cox regression model.

RESULTS: Self-assessed health status was completed by 266 (67%) patients with a mean age of 68.0 years (± 11.8), 54 (20%) were females, and 86 (32%) had one or more major concurrent medical conditions besides endocarditis. The self-assessed health status distribution was poor (n = 21, 8%) and non-poor (n = 245, 92%). The median follow-up was 3.3 years and death occurred in 9 (43%) and 48 (20%) patients reporting poor and non-poor health status, respectively, and mortality rates [mortality/100 person-years, 95% confidence interval (CI)] were 18.1 (95% CI 9.4-34.8) and 5.4 (95% CI 4.1-7.2), i.e., the crude hazard ratio for death was 3.4 (95% CI: 1.7-7.0, p < 0.01).

CONCLUSION: Self-assessed poor health status compared with non-poor health status as assessed by a single question was associated with a threefold increased long-term mortality in patients with endocarditis. POET ClinicalTrials.gov number, NCT01375257.

TRIAL REGISTRY: POET ClinicalTrials.gov number, NCT01375257.

Originalsprog	Engelsk
Sider (fra-til)	2655-2662
Antal sider	8
Tidsskrift	Quality of Life Research
Vol/bind	31
Udgave nummer	9
Tidlig onlinedato	29 mar. 2022
DOI	https://doi.org/10.1007/s11136-022-03126-x
Status	Udgivet - sep. 2022

Bibliografisk note

Adgang til dokumentet

10.1007/s11136-022-03126-x

Citationsformater

Bundgaard, J. S., Iversen, K., Pries-Heje, M., Ihlemann, N., Gill, S. U., Madsen, T., Elming, H., Povlsen, J. A., Bruun, N. E., Høfsten, D. E., Fuursted, K., Christensen, J. J., Schultz, M., Rosenvinge, F., Helweg-Larsen, J., Køber, L., Torp-Pedersen, C., Fosbøl, E. L., Tønder, N., ... Mogensen, U. M. (2022). Self-assessed health status and associated mortality in endocarditis: secondary findings from the POET trial. Quality of Life Research, 31(9), 2655-2662. https://doi.org/10.1007/s11136-022-03126-x

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title = "Self-assessed health status and associated mortality in endocarditis: secondary findings from the POET trial",

abstract = "PURPOSE: Self-assessed poor health status is associated with increased risk of mortality in several cardiovascular conditions, but has not been investigated in patients with endocarditis. We examined health status and mortality in patients with endocarditis.METHODS: This is a re-specified substudy of the randomized POET endocarditis trial, which included 400 patients. Patients completed the single-question self-assessed health status from the Short-Form 36 questionnaire at time of randomization and were categorized as having poor or non-poor (excellent/very good, good, or fair) health status. Self-assessed health status and all-cause mortality were examined by a Cox regression model.RESULTS: Self-assessed health status was completed by 266 (67%) patients with a mean age of 68.0 years (± 11.8), 54 (20%) were females, and 86 (32%) had one or more major concurrent medical conditions besides endocarditis. The self-assessed health status distribution was poor (n = 21, 8%) and non-poor (n = 245, 92%). The median follow-up was 3.3 years and death occurred in 9 (43%) and 48 (20%) patients reporting poor and non-poor health status, respectively, and mortality rates [mortality/100 person-years, 95% confidence interval (CI)] were 18.1 (95% CI 9.4-34.8) and 5.4 (95% CI 4.1-7.2), i.e., the crude hazard ratio for death was 3.4 (95% CI: 1.7-7.0, p < 0.01).CONCLUSION: Self-assessed poor health status compared with non-poor health status as assessed by a single question was associated with a threefold increased long-term mortality in patients with endocarditis. POET ClinicalTrials.gov number, NCT01375257.TRIAL REGISTRY: POET ClinicalTrials.gov number, NCT01375257.",

keywords = "Aged, Endocarditis, Female, Health Status, Humans, Male, Proportional Hazards Models, Quality of Life/psychology, Surveys and Questionnaires",

author = "Bundgaard, {Johan S} and Kasper Iversen and Mia Pries-Heje and Nikolaj Ihlemann and Gill, {Sabine U} and Trine Madsen and Hanne Elming and Povlsen, {Jonas A} and Bruun, {Niels E} and H{\o}fsten, {Dan E} and Kurt Fuursted and Christensen, {Jens J} and Martin Schultz and Flemming Rosenvinge and Jannik Helweg-Larsen and Lars K{\o}ber and Christian Torp-Pedersen and Fosb{\o}l, {Emil L} and Niels T{\o}nder and Claus Moser and Henning Bundgaard and Mogensen, {Ulrik M}",

note = "{\textcopyright} 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.",

year = "2022",

month = sep,

doi = "10.1007/s11136-022-03126-x",

language = "English",

volume = "31",

pages = "2655--2662",

journal = "Quality of Life Research",

issn = "0962-9343",

publisher = "Springer Netherlands",

number = "9",

}

Bundgaard, JS, Iversen, K, Pries-Heje, M, Ihlemann, N, Gill, SU, Madsen, T, Elming, H, Povlsen, JA, Bruun, NE, Høfsten, DE, Fuursted, K, Christensen, JJ, Schultz, M, Rosenvinge, F, Helweg-Larsen, J, Køber, L, Torp-Pedersen, C, Fosbøl, EL, Tønder, N, Moser, C, Bundgaard, H & Mogensen, UM 2022, 'Self-assessed health status and associated mortality in endocarditis: secondary findings from the POET trial', Quality of Life Research, bind 31, nr. 9, s. 2655-2662. https://doi.org/10.1007/s11136-022-03126-x

TY - JOUR

T1 - Self-assessed health status and associated mortality in endocarditis

T2 - secondary findings from the POET trial

AU - Bundgaard, Johan S

AU - Iversen, Kasper

AU - Pries-Heje, Mia

AU - Ihlemann, Nikolaj

AU - Gill, Sabine U

AU - Madsen, Trine

AU - Elming, Hanne

AU - Povlsen, Jonas A

AU - Bruun, Niels E

AU - Høfsten, Dan E

AU - Fuursted, Kurt

AU - Christensen, Jens J

AU - Schultz, Martin

AU - Rosenvinge, Flemming

AU - Helweg-Larsen, Jannik

AU - Køber, Lars

AU - Torp-Pedersen, Christian

AU - Fosbøl, Emil L

AU - Tønder, Niels

AU - Moser, Claus

AU - Bundgaard, Henning

AU - Mogensen, Ulrik M

PY - 2022/9

Y1 - 2022/9

N2 - PURPOSE: Self-assessed poor health status is associated with increased risk of mortality in several cardiovascular conditions, but has not been investigated in patients with endocarditis. We examined health status and mortality in patients with endocarditis.METHODS: This is a re-specified substudy of the randomized POET endocarditis trial, which included 400 patients. Patients completed the single-question self-assessed health status from the Short-Form 36 questionnaire at time of randomization and were categorized as having poor or non-poor (excellent/very good, good, or fair) health status. Self-assessed health status and all-cause mortality were examined by a Cox regression model.RESULTS: Self-assessed health status was completed by 266 (67%) patients with a mean age of 68.0 years (± 11.8), 54 (20%) were females, and 86 (32%) had one or more major concurrent medical conditions besides endocarditis. The self-assessed health status distribution was poor (n = 21, 8%) and non-poor (n = 245, 92%). The median follow-up was 3.3 years and death occurred in 9 (43%) and 48 (20%) patients reporting poor and non-poor health status, respectively, and mortality rates [mortality/100 person-years, 95% confidence interval (CI)] were 18.1 (95% CI 9.4-34.8) and 5.4 (95% CI 4.1-7.2), i.e., the crude hazard ratio for death was 3.4 (95% CI: 1.7-7.0, p < 0.01).CONCLUSION: Self-assessed poor health status compared with non-poor health status as assessed by a single question was associated with a threefold increased long-term mortality in patients with endocarditis. POET ClinicalTrials.gov number, NCT01375257.TRIAL REGISTRY: POET ClinicalTrials.gov number, NCT01375257.

AB - PURPOSE: Self-assessed poor health status is associated with increased risk of mortality in several cardiovascular conditions, but has not been investigated in patients with endocarditis. We examined health status and mortality in patients with endocarditis.METHODS: This is a re-specified substudy of the randomized POET endocarditis trial, which included 400 patients. Patients completed the single-question self-assessed health status from the Short-Form 36 questionnaire at time of randomization and were categorized as having poor or non-poor (excellent/very good, good, or fair) health status. Self-assessed health status and all-cause mortality were examined by a Cox regression model.RESULTS: Self-assessed health status was completed by 266 (67%) patients with a mean age of 68.0 years (± 11.8), 54 (20%) were females, and 86 (32%) had one or more major concurrent medical conditions besides endocarditis. The self-assessed health status distribution was poor (n = 21, 8%) and non-poor (n = 245, 92%). The median follow-up was 3.3 years and death occurred in 9 (43%) and 48 (20%) patients reporting poor and non-poor health status, respectively, and mortality rates [mortality/100 person-years, 95% confidence interval (CI)] were 18.1 (95% CI 9.4-34.8) and 5.4 (95% CI 4.1-7.2), i.e., the crude hazard ratio for death was 3.4 (95% CI: 1.7-7.0, p < 0.01).CONCLUSION: Self-assessed poor health status compared with non-poor health status as assessed by a single question was associated with a threefold increased long-term mortality in patients with endocarditis. POET ClinicalTrials.gov number, NCT01375257.TRIAL REGISTRY: POET ClinicalTrials.gov number, NCT01375257.

KW - Aged

KW - Endocarditis

KW - Female

KW - Health Status

KW - Humans

KW - Male

KW - Proportional Hazards Models

KW - Quality of Life/psychology

KW - Surveys and Questionnaires

U2 - 10.1007/s11136-022-03126-x

DO - 10.1007/s11136-022-03126-x

M3 - Article

C2 - 35349038

SN - 0962-9343

VL - 31

SP - 2655

EP - 2662

JO - Quality of Life Research

JF - Quality of Life Research

IS - 9

ER -

Self-assessed health status and associated mortality in endocarditis: secondary findings from the POET trial

Abstract

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