Role of B-cells in Mycosis Fungoides

Pia Rude Nielsen, Jens Ole Eriksen, Mia Dahl Sørensen, Ulrike Wehkamp, Lise M. Lindahl, Michael Bzorek, Lars Iversen, Anders Woetman, Niels Ødum, Thomas Litman, Lise Mette Rahbek Gjerdrum

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Abstrakt

Mycosis fungoides is the most common type of cutaneous T-cell lymphoma. The inflammatory micro-environment in mycosis fungoides is complex. There is accumulating evidence that the neoplastic T-cells take control of the microenvironment and thereby promote their own expansion by suppressing cellular immunity. B-cells have proved to be upregulated in large-cell transformed mycosis fungoides, and could potentially play a role in disease progression. To investigate the presence of B-cells in mycosis fungoides compared with controls, this study analysed 85 formalin-fixed and paraffin-embedded mycosis fungoides biopsies. MS4A1 gene expression was significantly upregulated in mycosis fungoides compared with controls (p < 0.0001) and further upregulated in disease progression, (p = 0.001). Digital quantification of PAX5+/CD20+ cells confirmed the increased presence of B-cells in mycosis fungoides compared with controls. No co-labelling of CD3/CD20 was observed in the neoplastic T-cells. This study found a significantly increased presence of B-cells in the tumour-associated microenvironment in mycosis fungoides. These findings could potentially lead to new treatment strategies for mycosis fungoides.

OriginalsprogEngelsk
Artikelnummeradv00413
TidsskriftActa Dermato-Venereologica
Vol/bind101
Udgave nummer3
DOI
StatusUdgivet - 11 mar. 2021

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