Risk of subarachnoid haemorrhages and aneurysms in Danish People Living With HIV, a nationwide cohort study

Malte M Tetens*, Jan Gerstoft, Gitte Kronborg, Isik S Johansen, Carsten S Larsen, Lothar Wiese, Michael Dalager-Pedersen, Lars H Omland, Niels Obel

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstrakt

OBJECTIVE: It remains unclear whether People Living With HIV (PLWH) have increased risk of aneurisms. We aimed to investigate if the risk of subarachnoid haemorrhage, cerebral aneurysm, aortic aneurysm and other arterial aneurysms and dissections is increased in PLWH compared with the general population.

DESIGN: We performed a nationwide population-based matched cohort study.

METHODS: We compared PLWH with age and sex matched comparison cohort members to calculate incidence rate ratios (IRR) of subarachnoid haemorrhage, cerebral aneurysm, aortic aneurysm and other arterial aneurysms and dissections as well as surgery for these conditions.

RESULTS: We included all PLWH, who were Danish residents and treated at a HIV health care centre between January 1995 and February 2018 (n = 6 935) and an age- and sex-matched comparison cohort (n = 55 480). PLWH had increased risk of subarachnoid haemorrhage (IRR 1.7, 95% CI, 1.1-2.6), but no increased risk of surgery for this condition. PLWH had no increased risk of cerebral aneurysm or aortic aneurysm or surgery for these conditions. The risk of other arterial aneurysms and dissections was increased in PLWH (IRR 2.0, 95% CI, 1.4-2.9), but this only applied for PLWH who reported IV-substance use as route of HIV-transmission (IRR 18.4, 95% CI, 9.3-36.6), and not for PLWH without reported injection drug use (IRR 1.2, 95% CI, 0.73-1.7).

CONCLUSION: PLWH were not at an increased risk of cerebral, aortic or other arterial aneurysms and dissections. Although PLWH were at an increased risk of subarachnoid haemorrhage, subarachnoid haemorrhages were rare among PLWH.

OriginalsprogEngelsk
TidsskriftAIDS (London, England)
DOI
StatusUdgivet, E-publikation før trykning - 27 apr. 2022

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