TY - JOUR
T1 - Risk of heart failure among individuals tested for Borrelia burgdorferi sensu lato antibodies, and serum Borrelia burgdorferi sensu lato seropositive individuals; a nationwide population-based, registry-based matched cohort study
AU - Tetens, Malte Mose
AU - Omland, Lars Haukali
AU - Dessau, Ram B
AU - Ellermann-Eriksen, Svend
AU - Andersen, Nanna S.
AU - Jørgensen, Charlotte Sværke
AU - Østergaard, Christian
AU - Bodilsen, Jacob
AU - Søgaard, Kirstine Kobberøe
AU - Bangsborg, Jette M.
AU - Nielsen, Alex Christian Yde
AU - Møller, Jens Kjølseth
AU - Chen, Ming
AU - Svendsen, Jesper Hastrup
AU - Obel, Niels
AU - Lebech, Anne Mette
N1 - Copyright © 2024 The Authors. Published by Elsevier GmbH.. All rights reserved.
PY - 2024/7
Y1 - 2024/7
N2 - BACKGROUND: Lyme borreliosis is a tick-borne disease caused by the bacterium Borrelia burgdorferi (Bb) sensu lato complex. Previous studies have suggested an association between Lyme borreliosis and heart failure, which have been suggested to be a possible manifestation of Lyme carditis. We aimed to investigate the risk of heart failure among individuals tested for serum Bb antibodies, and serum Bb seropositive individuals.METHODS: We performed a matched nationwide cohort study (Denmark, 1993-2020) and included 52,200 Bb seropositive individuals, and two age- and sex-matched comparison cohorts: 1) 104,400 Bb seronegative comparison cohort members, and 2) 261,000 population controls. We investigated the risk associated with 1) being tested for serum Bb antibodies, and 2) being Bb seropositive. Outcomes were: 1) a composite of heart failure, cardiomyopathy, and/or myocarditis diagnosis, and 2) redemption of cardiovascular medicine used for treatment of heart failure. We calculated short-term odds ratios (aOR) (within 1 month) and long-term hazard rates (aHR) (after 1 month) adjusted for age, sex, diabetes, pre-existing heart failure, and kidney disease.RESULTS: Compared with the population controls, individuals tested for Bb antibodies, regardless of the test result, had increased short-term risk of heart failure, cardiomyopathy, and myocarditis (aOR 8.3, 95 %CI: 6.7-10.2), and both increased short- and long-term risk of redemption of cardiovascular medicine (aOR 4.3, 95 %CI: 3.8-4.8, aHR 1.13, 95 % CI: 1.11-1.15). The Bb seropositive individuals had no increased short- or long-term risk of any outcome compared with Bb seronegative comparison cohort members.CONCLUSIONS: In conclusion, Bb antibody tests seemed to be performed in the diagnostic work-up of heart failure, but Bb seropositivity was not associated with heart failure.
AB - BACKGROUND: Lyme borreliosis is a tick-borne disease caused by the bacterium Borrelia burgdorferi (Bb) sensu lato complex. Previous studies have suggested an association between Lyme borreliosis and heart failure, which have been suggested to be a possible manifestation of Lyme carditis. We aimed to investigate the risk of heart failure among individuals tested for serum Bb antibodies, and serum Bb seropositive individuals.METHODS: We performed a matched nationwide cohort study (Denmark, 1993-2020) and included 52,200 Bb seropositive individuals, and two age- and sex-matched comparison cohorts: 1) 104,400 Bb seronegative comparison cohort members, and 2) 261,000 population controls. We investigated the risk associated with 1) being tested for serum Bb antibodies, and 2) being Bb seropositive. Outcomes were: 1) a composite of heart failure, cardiomyopathy, and/or myocarditis diagnosis, and 2) redemption of cardiovascular medicine used for treatment of heart failure. We calculated short-term odds ratios (aOR) (within 1 month) and long-term hazard rates (aHR) (after 1 month) adjusted for age, sex, diabetes, pre-existing heart failure, and kidney disease.RESULTS: Compared with the population controls, individuals tested for Bb antibodies, regardless of the test result, had increased short-term risk of heart failure, cardiomyopathy, and myocarditis (aOR 8.3, 95 %CI: 6.7-10.2), and both increased short- and long-term risk of redemption of cardiovascular medicine (aOR 4.3, 95 %CI: 3.8-4.8, aHR 1.13, 95 % CI: 1.11-1.15). The Bb seropositive individuals had no increased short- or long-term risk of any outcome compared with Bb seronegative comparison cohort members.CONCLUSIONS: In conclusion, Bb antibody tests seemed to be performed in the diagnostic work-up of heart failure, but Bb seropositivity was not associated with heart failure.
KW - Adolescent
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Antibodies, Bacterial/blood
KW - Borrelia burgdorferi Group/immunology
KW - Borrelia burgdorferi/immunology
KW - Cohort Studies
KW - Female
KW - Heart Failure/epidemiology
KW - Humans
KW - Lyme Disease/epidemiology
KW - Male
KW - Middle Aged
KW - Registries
KW - Risk Factors
KW - Young Adult
U2 - 10.1016/j.ttbdis.2024.102345
DO - 10.1016/j.ttbdis.2024.102345
M3 - Article
C2 - 38636178
SN - 1877-959X
VL - 15
JO - Ticks and Tick-borne Diseases
JF - Ticks and Tick-borne Diseases
IS - 4
M1 - 102345
ER -