Risk of cardiovascular events in men treated for prostate cancer compared with prostate cancer-free men

Ida Rask Moustsen, Signe Benzon Larsen, Anne Katrine Duun-Henriksen, Anne Tjønneland, Susanne K Kjær, Klaus Brasso, Christoffer Johansen, Susanne Oksbjerg Dalton

Publikation: Bidrag til tidsskriftArtikelForskningpeer review


BACKGROUND: The effect of lifestyle, anthropometry and cardiovascular risk factors on cardiovascular disease in men with prostate cancer (PCa) remains unclear.

METHODS: Using a population-based cohort of 25,436 Danish, cancer-free men aged 50-64 years, we obtained information on self-reported pre-cancer lifestyle, objectively measured anthropometry and cardiovascular risk factors, and linked them to national health registers for information on major cardiovascular outcomes. We assessed hazard ratios (HRs) of incident acute myocardial infarction (MI), ischaemic stroke (IS) and heart failure (HF) among 1546 men diagnosed with PCa treated with first-line active surveillance, watchful waiting, intended curative or palliative treatment compared with PCa-free men during 18 years of follow-up.

RESULTS: Men who received first-line palliative treatment had higher rates of IS and HF with adjusted HRs of 2.09 (95% CI 1.49-2.93) and 2.05 (95% CI 1.43-2.94), respectively, compared with PCa-free men. The risks were increased from start of treatment. We did not find the same relation for men in any other treatment group. No differences between men treated for PCa and cancer-free controls were observed for MI after adjustment for lifestyle, anthropometry, and cardiovascular risk factors.

CONCLUSION: Pre-diagnosis lifestyle, anthropometry or cardiovascular risk factors did not explain the risk of IS and HF in PCa patients receiving palliative treatment. The results emphasise the need for balancing disease management and monitoring of cardiovascular health in this patient group.

Sider (fra-til)1067-1074
Antal sider8
TidsskriftBritish Journal of Cancer
Udgave nummer11
StatusUdgivet - 2019


Udforsk hvilke forskningsemner 'Risk of cardiovascular events in men treated for prostate cancer compared with prostate cancer-free men' indeholder.