Risk of cancer and exposure to gasoline vapors

Elsebeth Lynge*, Aage Andersen, Ralph Nilsson, Lotti Barlow, Eero Pukkala, Rolf Nordlinder, Paolo Boffetta, Philippe Grandjean, Pirjo Heikkilä, Lars Gunnar Hörte, Robert Jakobsson, Inqvar Lundberg, Bente Moen, Timo Partanen, Trond Riise

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelpeer review

    Abstract

    Until the introduction of self-service around 1970, service station workers in the Nordic countries were exposed to gasoline vapors. Based on measurements reported in the literature, the 8-hour time-weighted average benzene exposure was estimated to be in the range of 0.5-1 mg/m3. We studied the cancer incidence in a cohort of 19,000 service station workers from Denmark, Norway, Sweden, and Finland. They were identified from the 1970 censuses and followed through 20 years, where 1,300 incident cancers were observed. National incidence rates were used for comparison. The incidence was not increased for leukemia (observed = 28, standardized incidence ratio (SIR) = 0.9, 95% confidence interval (CI) 0.6-1.3) nor for acute myeloid leukemia (observed = 13, SIR = 1.3, 95% CI 0.7-2.1). The incidence was slightly elevated for kidney cancer (observed = 57, SIR = 1.3, 95% CI 1.0- 1.7) and for pharyngeal, laryngeal, and lung cancer. A 3.5-fold risk of nasal cancer was found (observed = 12, SIR = 3.5, 95% CI 1.8-6.1). This cohort exposed to gasoline vapors with benzene levels estimated to be 0.5-1 mg/m3 showed no excess risk of leukemia or acute myeloid leukemia, a 30% elevated risk of kidney cancer, and a previously unnoticed risk of nasal cancer.

    OriginalsprogEngelsk
    Sider (fra-til)449-458
    Antal sider10
    TidsskriftAmerican Journal of Epidemiology
    Vol/bind145
    Udgave nummer5
    DOI
    StatusUdgivet - 1 jan. 1997

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