Risk factors and age-related patterns of asthma-like symptoms in early childhood

Julie Nyholm Kyvsgaard, Bo Lund Krogsgaard Chawes, David Lyle George Horner, Laura Marie Hesselberg, Mathias Elsner Melgaard, Signe Kjeldgaard Jensen, Ann-Marie Malby Schoos, Jonathan Thorsen, Casper-Emil Tingskov Pedersen, Nicklas Brustad, Klaus Bønnelykke, Hans Bisgaard, Jakob Stokholm*

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftArtikelForskningpeer review


BACKGROUND: Episodes of asthma-like symptoms in young children are common, but little is known about risk factors and their patterns for the daily symptom burden.

OBJECTIVE: We investigated a variety of possible risk factors and their age-related impact on the number of asthma-like episodes during age 0 to 3 years.

METHODS: The study population included 700 children from the Copenhagen Prospective Studies on Asthma in Childhood 20 1 0 mother-child cohort followed prospectively from birth. Asthma-like symptoms were recorded until age 3 by daily diaries. Risk factors were analyzed by quasi-Poisson regressions, and interaction with age was explored.

RESULTS: Diary data were available in 662 children. Male sex, maternal asthma, low birth weight, maternal antibiotic use, high asthma exacerbation polygenic risk score, and high airway immune score were associated with a higher number of episodes in a multivariable analysis. Maternal asthma, preterm birth, caesarean section, and low birth weight showed an increasing impact with age, whereas sibling(s) at birth showed a decreased association with age. The remaining risk factors had a stable pattern during age 0 to 3 years. For every additional clinical risk factor (male sex, low birth weight, and maternal asthma) a child had, we found 34% more episodes (incidence rate ratio: 1.34, 95% confidence interval: 1.21-1.48; P < .001).

CONCLUSION: Using unique day-to-day diary recordings, we identified risk factors for the burden of asthma-like symptoms in the first 3 years of life and described their unique age-related patterns. This provides novel insight into the origin of asthma-like symptoms in early childhood that potentially pave a path for personalized prognostics and treatment.

Sider (fra-til)1773-1784.e10
TidsskriftJournal of Allergy and Clinical Immunology: In Practice
Udgave nummer6
Tidlig onlinedato6 mar. 2023
StatusUdgivet - jun. 2023

Bibliografisk note

Copyright © 2023 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.


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