Risiko for anastomoselækage ved postoperativ behandling med nonsteroide antiinflammatoriske stoffer

Mads Klein, Ismail Gögenur, Jacob Rosenberg

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    Anastomotic leakage is the most serious complication following colorectal resection. Recently, focus has been on possible effects of non-steroidal anti-inflammatory drugs (NSAIDs). Animal studies have found a correlation between treatment with NSAIDs and increased leakage rate, impaired anastomotic strength and reduced deposition of hydroxyproline. Retrospective human studies have reported increased leakage rates after postoperative diclofenac and celecoxib treatment. We recommend that diclofenac and celecoxib be omitted from analgesic regimens after colorectal surgery involving an anastomosis.

    Bidragets oversatte titelRisk of anastomotic leakage in postoperative treatment with non-steroidal anti-inflammatory drugs
    OriginalsprogDansk
    TidsskriftUgeskrift for laeger
    Vol/bind172
    Udgave nummer22
    StatusUdgivet - 1 maj 2010

    Fingeraftryk Udforsk hvilke forskningsemner 'Risiko for anastomoselækage ved postoperativ behandling med nonsteroide antiinflammatoriske stoffer' indeholder.

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