Richter’s transformation in patients with chronic lymphocytic leukaemia: a Nationwide Epidemiological Study

Yasmin Ben-Dali, Mariam H. Hleuhel, Caspar da Cunha-Bang, Christian Brieghel, Christian B. Poulsen, Erik Clasen-Linde, Hans H.N. Bentzen, Henrik Frederiksen, Ilse Christiansen, Linda H. Nielsen, Lisbeth Enggaard, Marie Helleberg, Michael Clausen, Mikael Frederiksen, Robert S. Pedersen, Carsten U. Niemann, Michael A. Andersen

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstrakt

Richter’s transformation (RT) refers to the development of an aggressive lymphoma in patients with chronic lymphocytic leukemia (CLL). Approximately, 2–10% of patients with CLL develop RT, most often as diffuse large B-cell lymphoma. To assess the incidence of RT, we examined risk factors for RT and death among patients with RT in a nationwide CLL cohort (from 2008 to 2016). Among 3772 patients, 113 had biopsy-proven RT. With a median follow-up of 4.3 years, the 5-year cumulative incidence of RT was 2.8%. Advanced Binet stage (B/C) (p<.001), unmutated IGHV (p<.001), and del(17p) (p<.001) were independently associated with risk of developing RT. Half of the patients with RT (49%) were treatment-naïve prior to transformation and demonstrated longer survival after RT compared to patients previously treated for CLL (6.1 vs. 2.8 years, p=.03). Whether this finding could be explained by a higher proportion of clonally unrelated RT among treatment-naïve patients, remain to be addressed.

OriginalsprogEngelsk
Sider (fra-til)1435-1444
Antal sider10
TidsskriftLeukemia and Lymphoma
Vol/bind61
Udgave nummer6
DOI
StatusUdgivet - jun. 2020

Fingeraftryk Udforsk hvilke forskningsemner 'Richter’s transformation in patients with chronic lymphocytic leukaemia: a Nationwide Epidemiological Study' indeholder.

Citationsformater