Revaccination against tetanus 17 to 20 years after primary vaccination: Kinetics of antibody response

O. Simonsen*, M. Klærke, J. E. Jensen, K. Kjeldsen, C. Hau, I. Heron

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    In 24 military recruits vaccinated against tetanus 17-20 years earlier antibody responses were studied 4, 11, and 24 days after revaccination. Antitoxin concentration in serum showed a sigmoid increase with titres at day 4 only just above protective level, corresponding to a risk of susceptibility to be expected even 4 days after revaccination (2.0%, 95% confidence limit). Only after 7 days the risk of unprotection was less than l%o. As the incubation period of tetanus can be as short as 24 hours, revaccination only may not be regarded sufficient if more than 17-20 years have elapsed since primary vaccination and conditions favoring rapid development of tetanus are present. The findings may explain some of the cases of tetanus which have occurred in spite of primary vaccination supplemented by emergency booster. The statement that prophylactic tetanus immunoglobulin is never indicated to persons completely vaccinated earlier should be considered for revision.

    OriginalsprogEngelsk
    Sider (fra-til)1358-1361
    Antal sider4
    TidsskriftJournal of Trauma - Injury, Infection and Critical Care
    Vol/bind27
    Udgave nummer12
    DOI
    StatusUdgivet - dec. 1987

    Fingeraftryk

    Udforsk hvilke forskningsemner 'Revaccination against tetanus 17 to 20 years after primary vaccination: Kinetics of antibody response' indeholder.

    Citationsformater