Relation of left ventricular function, mass, and volume to NT-proBNP in type 1 diabetic patients

Anne Sofie Astrup; Won Yong Kim; Lise Tarnow; René M. Botnar; Cheryl Simonsen; Lau Brix; Lotte Pietraszek; Peter Riis Hansen; Warren J. Manning; Hans Henrik Parving

doi:10.2337/dc07-1536

Relation of left ventricular function, mass, and volume to NT-proBNP in type 1 diabetic patients

Anne Sofie Astrup, Won Yong Kim, Lise Tarnow, René M. Botnar, Cheryl Simonsen, Lau Brix, Lotte Pietraszek, Peter Riis Hansen, Warren J. Manning, Hans Henrik Parving

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

OBJECTIVES - To measure left ventricular mass (LVM), left ventricular volumes, and left ventricular function (LVF) in a cohort of type 1 diabetic patients and to correlate measures of imaging to NH ₂-terminal pro-brain natriuretic peptide (NT-proBNP). RESEARCH DESIGN AND METHODS - In a cross-sectional study, all patients with type 1 diabetes underwent cardiovascular magnetic resonance imaging. We included 63 patients with diabetic nephropathy and 73 patients with normoalbuminuria. RESULTS - All patients had normal global LVF. LVM was increased in patients with diabetic nephropathy compared with patients with persistent normoalbuminuria. Patients with nephrop- athy had smaller left ventricular volumes and increased levels of NT-proBNP. Linear regression analysis in patients with diabetic nephropathy showed that NT-proBNP and creatinine were associated with LVM. CONCLUSIONS - Increased LVM is identified in asymptomatic type 1 diabetic patients with nephropathy compared with normoalbuminuric patients. Elevated levels of NT-proBNP were associated with increased LVM, which are both markers of increased cardiovascular risk.

Originalsprog	Engelsk
Sider (fra-til)	968-970
Antal sider	3
Tidsskrift	Diabetes Care
Vol/bind	31
Udgave nummer	5
DOI	https://doi.org/10.2337/dc07-1536
Status	Udgivet - 1 maj 2008

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title = "Relation of left ventricular function, mass, and volume to NT-proBNP in type 1 diabetic patients",

abstract = "OBJECTIVES - To measure left ventricular mass (LVM), left ventricular volumes, and left ventricular function (LVF) in a cohort of type 1 diabetic patients and to correlate measures of imaging to NH 2-terminal pro-brain natriuretic peptide (NT-proBNP). RESEARCH DESIGN AND METHODS - In a cross-sectional study, all patients with type 1 diabetes underwent cardiovascular magnetic resonance imaging. We included 63 patients with diabetic nephropathy and 73 patients with normoalbuminuria. RESULTS - All patients had normal global LVF. LVM was increased in patients with diabetic nephropathy compared with patients with persistent normoalbuminuria. Patients with nephrop- athy had smaller left ventricular volumes and increased levels of NT-proBNP. Linear regression analysis in patients with diabetic nephropathy showed that NT-proBNP and creatinine were associated with LVM. CONCLUSIONS - Increased LVM is identified in asymptomatic type 1 diabetic patients with nephropathy compared with normoalbuminuric patients. Elevated levels of NT-proBNP were associated with increased LVM, which are both markers of increased cardiovascular risk.",

author = "Astrup, {Anne Sofie} and Kim, {Won Yong} and Lise Tarnow and Botnar, {Ren{\'e} M.} and Cheryl Simonsen and Lau Brix and Lotte Pietraszek and Hansen, {Peter Riis} and Manning, {Warren J.} and Parving, {Hans Henrik}",

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Relation of left ventricular function, mass, and volume to NT-proBNP in type 1 diabetic patients. / Astrup, Anne Sofie; Kim, Won Yong; Tarnow, Lise; Botnar, René M.; Simonsen, Cheryl; Brix, Lau; Pietraszek, Lotte; Hansen, Peter Riis; Manning, Warren J.; Parving, Hans Henrik.

I: Diabetes Care, Bind 31, Nr. 5, 01.05.2008, s. 968-970.

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

TY - JOUR

T1 - Relation of left ventricular function, mass, and volume to NT-proBNP in type 1 diabetic patients

AU - Astrup, Anne Sofie

AU - Kim, Won Yong

AU - Tarnow, Lise

AU - Botnar, René M.

AU - Simonsen, Cheryl

AU - Brix, Lau

AU - Pietraszek, Lotte

AU - Hansen, Peter Riis

AU - Manning, Warren J.

AU - Parving, Hans Henrik

PY - 2008/5/1

Y1 - 2008/5/1

N2 - OBJECTIVES - To measure left ventricular mass (LVM), left ventricular volumes, and left ventricular function (LVF) in a cohort of type 1 diabetic patients and to correlate measures of imaging to NH 2-terminal pro-brain natriuretic peptide (NT-proBNP). RESEARCH DESIGN AND METHODS - In a cross-sectional study, all patients with type 1 diabetes underwent cardiovascular magnetic resonance imaging. We included 63 patients with diabetic nephropathy and 73 patients with normoalbuminuria. RESULTS - All patients had normal global LVF. LVM was increased in patients with diabetic nephropathy compared with patients with persistent normoalbuminuria. Patients with nephrop- athy had smaller left ventricular volumes and increased levels of NT-proBNP. Linear regression analysis in patients with diabetic nephropathy showed that NT-proBNP and creatinine were associated with LVM. CONCLUSIONS - Increased LVM is identified in asymptomatic type 1 diabetic patients with nephropathy compared with normoalbuminuric patients. Elevated levels of NT-proBNP were associated with increased LVM, which are both markers of increased cardiovascular risk.

AB - OBJECTIVES - To measure left ventricular mass (LVM), left ventricular volumes, and left ventricular function (LVF) in a cohort of type 1 diabetic patients and to correlate measures of imaging to NH 2-terminal pro-brain natriuretic peptide (NT-proBNP). RESEARCH DESIGN AND METHODS - In a cross-sectional study, all patients with type 1 diabetes underwent cardiovascular magnetic resonance imaging. We included 63 patients with diabetic nephropathy and 73 patients with normoalbuminuria. RESULTS - All patients had normal global LVF. LVM was increased in patients with diabetic nephropathy compared with patients with persistent normoalbuminuria. Patients with nephrop- athy had smaller left ventricular volumes and increased levels of NT-proBNP. Linear regression analysis in patients with diabetic nephropathy showed that NT-proBNP and creatinine were associated with LVM. CONCLUSIONS - Increased LVM is identified in asymptomatic type 1 diabetic patients with nephropathy compared with normoalbuminuric patients. Elevated levels of NT-proBNP were associated with increased LVM, which are both markers of increased cardiovascular risk.

UR - http://www.scopus.com/inward/record.url?scp=48649107804&partnerID=8YFLogxK

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AN - SCOPUS:48649107804

VL - 31

SP - 968

EP - 970

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 5

ER -

Relation of left ventricular function, mass, and volume to NT-proBNP in type 1 diabetic patients

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