TY - JOUR
T1 - Relation of left ventricular function and Na,K-pump concentration in suspected idiopathic dilated cardiomyopathy
AU - Nørgaard, Aage
AU - Bagger, Jens P.
AU - Bjerregaard, Preben
AU - Baandrup, Ulrik
AU - Kjeldsen, Keld
AU - Thomsen, Poul E.B.
PY - 1988/6/1
Y1 - 1988/6/1
N2 - The possible relation between Na,K-pump concentration and left ventricular (LV) function was studied in 24 patients with suspected idiopathic dilated cardiomyopathy. This was done by measurement of 3H-ouabain binding to biopsies obtained during left-sided heart catheterization. In all patients light microscopy of biopsies was compatible with dilated cardiomyopathy. Nineteen patients had impaired LV function as defined by NYHA/WHO and a Na,K-pump concentration of 331 ± 19 pmol/g wet weight, wheras 5 patients had normal LV function and a Na,K-pump concentration of 559 ± 62 pmol/ g wet weight (p < 0.001). The correlation between Na,K-pump concentration and ejection fraction was highly significant (n = 24, r = 0.81, p < 0.001). There was no correlation between volume fraction of collagen tissue and Na,K-pump concentration in the biopsies (n = 24, r = -0.08, p < 0.80), indicating that the decrease in Na,K-pump concentration with dilated cardiomyopathy is not the simple outcome of increased fibrosis in the myocardium. The results indicate that the decrease in Na,K-pump concentration may be of importance for myocardial dysfunction and suggest a simple biochemical assessment of dilated cardiomyopathy by measurement of 3H-ouabain binding.
AB - The possible relation between Na,K-pump concentration and left ventricular (LV) function was studied in 24 patients with suspected idiopathic dilated cardiomyopathy. This was done by measurement of 3H-ouabain binding to biopsies obtained during left-sided heart catheterization. In all patients light microscopy of biopsies was compatible with dilated cardiomyopathy. Nineteen patients had impaired LV function as defined by NYHA/WHO and a Na,K-pump concentration of 331 ± 19 pmol/g wet weight, wheras 5 patients had normal LV function and a Na,K-pump concentration of 559 ± 62 pmol/ g wet weight (p < 0.001). The correlation between Na,K-pump concentration and ejection fraction was highly significant (n = 24, r = 0.81, p < 0.001). There was no correlation between volume fraction of collagen tissue and Na,K-pump concentration in the biopsies (n = 24, r = -0.08, p < 0.80), indicating that the decrease in Na,K-pump concentration with dilated cardiomyopathy is not the simple outcome of increased fibrosis in the myocardium. The results indicate that the decrease in Na,K-pump concentration may be of importance for myocardial dysfunction and suggest a simple biochemical assessment of dilated cardiomyopathy by measurement of 3H-ouabain binding.
UR - http://www.scopus.com/inward/record.url?scp=0023939034&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(88)91175-7
DO - 10.1016/0002-9149(88)91175-7
M3 - Article
C2 - 3376892
AN - SCOPUS:0023939034
VL - 61
SP - 1312
EP - 1315
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 15
ER -