Reference values for fluorine-18-fluorodeoxyglucose and fluorine-18-sodium fluoride uptake in human arteries: A prospective evaluation of 89 healthy adults

Björn A. Blomberg, Anders Thomassen, Pim A. De Jong, Marnix G.E.H. Lam, Søren Hess, Michael H. Olsen, Willem P.T.M. Mali, Abass Alavi, Poul F. Høilund-Carlsen

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstrakt

Objective Reference values of fluorine-18-fluorodeoxyglucose (18F-FDG) and fluorine-18-sodium fluoride (18F-NaF) uptake in human arteries are unknown. The aim of this study was to determine age-specific and sex-specific reference values of arterial 18F-FDG and 18F-NaF uptake. Participants and methods Uptake of 18F-FDG and 18F-NaF was determined in the ascending aorta, aortic arch, and descending thoracic aorta. In addition, 18F-FDG uptake was determined in the carotid arteries and 18F-NaF uptake was determined in the coronary arteries. Arterial 18F-FDG and 18F-NaF uptake were quantified as the blood pool subtracted maximum activity concentration in kBq/ml (BS 18F-FDGmax and BS 18F-NaFmax, respectively). In addition to determining reference values, we evaluated the influence of age and sex on BS 18F-FDGmax and BS 18F-NaFmax. Results Arterial 18F-FDG and 18F-NaF uptake was assessed in 89 healthy adults aged 21-75 years (mean age: 44±14 years, 53% men). Both BS 18F-FDGmax and BS 18F-NaFmax increased with age. BS 18F-FDGmax increased with age in the descending aorta (β=0.28; P=0.003), whereas BS 18F-NaFmax increased with age in the ascending aorta (β=0.18; P<0.001), aortic arch (β=0.19; P=0.006), descending aorta (β=0.33; P<0.001), and coronary arteries (β=0.20; P=0.009), respectively. BS 18F-FDGmax and BS 18F-NaFmax were not influenced by sex, except for BS 18F-FDGmax in the ascending aorta. Conclusion Prospective evaluation of 89 healthy adults generated age-specific and sex-specific reference values of arterial 18F-FDG and 18F-NaF uptake. Our findings indicate that arterial 18F-FDG and 18F-NaF uptake tend to increase with age.

OriginalsprogEngelsk
Sider (fra-til)998-1006
Antal sider9
TidsskriftNuclear Medicine Communications
Vol/bind38
Udgave nummer11
DOI
StatusUdgivet - 1 jan. 2017

Fingeraftryk Udforsk hvilke forskningsemner 'Reference values for fluorine-18-fluorodeoxyglucose and fluorine-18-sodium fluoride uptake in human arteries: A prospective evaluation of 89 healthy adults' indeholder.

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