TY - JOUR
T1 - Reference values for fasting serum concentrations of thyroid-stimulating hormone and thyroid hormones in healthy Danish/North-European white children and adolescents
AU - Gunapalasingham, Gowthami
AU - Frithioff-Bøjsøe, Christine
AU - Lund, Morten Asp Vonsild
AU - Hedley, Paula Louise
AU - Fonvig, Cilius Esmann
AU - Dahl, Maria
AU - Pedersen, Oluf
AU - Christiansen, Michael
AU - Hansen, Torben
AU - Lausten-Thomsen, Ulrik
AU - Holm, Jens-Christian
PY - 2019/3/13
Y1 - 2019/3/13
N2 - Thyroid-stimulating hormone (TSH) and thyroid hormones influence the functions of many organ systems, as well as child development and growth. Several studies have reported an association between ethnicity and thyroid hormones. This study aims to explore pediatric serum concentrations of TSH, free triiodothyronine (fT3), and free thyroxine (fT4) and their relation to age and sex and subsequently to present pediatric reference intervals from healthy Danish/North-European white children. A population-based cohort in Denmark of 2411 (1435 girls) healthy school children and adolescents aged 6.0-18.9?years were included. Fasting concentrations of serum TSH, fT3, and fT4 were determined from venous blood samples using immunologic chemiluminescent assays. Age- and sex-dependent percentiles were generated using the GAMLSS function. Median values of fT3 and fT4, but not TSH, were lower in the older age group compared with the youngest age group for both sexes (all p?<?.05). A significant difference for fT3 was found between the sexes for all age groups (all p?<?.001). fT4 was negatively correlated with body mass index standard deviation scores in boys. In conclusion, serum concentrations of thyroid hormones vary during childhood and adolescence and differ with age and sex.
AB - Thyroid-stimulating hormone (TSH) and thyroid hormones influence the functions of many organ systems, as well as child development and growth. Several studies have reported an association between ethnicity and thyroid hormones. This study aims to explore pediatric serum concentrations of TSH, free triiodothyronine (fT3), and free thyroxine (fT4) and their relation to age and sex and subsequently to present pediatric reference intervals from healthy Danish/North-European white children. A population-based cohort in Denmark of 2411 (1435 girls) healthy school children and adolescents aged 6.0-18.9?years were included. Fasting concentrations of serum TSH, fT3, and fT4 were determined from venous blood samples using immunologic chemiluminescent assays. Age- and sex-dependent percentiles were generated using the GAMLSS function. Median values of fT3 and fT4, but not TSH, were lower in the older age group compared with the youngest age group for both sexes (all p?<?.05). A significant difference for fT3 was found between the sexes for all age groups (all p?<?.001). fT4 was negatively correlated with body mass index standard deviation scores in boys. In conclusion, serum concentrations of thyroid hormones vary during childhood and adolescence and differ with age and sex.
KW - Adolescent
KW - Age Factors
KW - Body Mass Index
KW - Child
KW - Cohort Studies
KW - Europe
KW - European Continental Ancestry Group
KW - Fasting/blood
KW - Female
KW - Healthy Volunteers
KW - Humans
KW - Immunoassay
KW - Luminescence
KW - Male
KW - Reference Values
KW - Sex Factors
KW - Thyrotropin/blood
KW - Thyroxine/blood
KW - Triiodothyronine/blood
KW - Young Adult
U2 - 10.1080/00365513.2019.1581945
DO - 10.1080/00365513.2019.1581945
M3 - Article
C2 - 30861348
VL - 79
SP - 129
EP - 135
JO - Scandinavian Journal of Clinical and Laboratory Investigation
JF - Scandinavian Journal of Clinical and Laboratory Investigation
SN - 0036-5513
IS - 1-2
ER -