Reduced levels of pulmonary surfactant in COVID-19 ARDS

Peter Schousboe*, Andreas Ronit*, Henning B Nielsen, Thomas Benfield, Lothar Wiese, Nikolaos Scoutaris, Henrik Verder, Ronan M G Berg, Povl Verder, Ronni R Plovsing

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftArtikelForskningpeer review


To provide novel data on surfactant levels in adult COVID-19 patients, we collected bronchoalveolar lavage fluid less than 72 h after intubation and used Fourier Transform Infrared Spectroscopy to measure levels of dipalmitoylphosphatidylcholine (DPPC). A total of eleven COVID-19 patients with moderate-to-severe ARDS (CARDS) and 15 healthy controls were included. CARDS patients had lower DPPC levels than healthy controls. Moreover, a principal component analysis was able to separate patient groups into distinguishable subgroups. Our findings indicate markedly impaired pulmonary surfactant levels in COVID-19 patients, justifying further studies and clinical trials of exogenous surfactant.

Sider (fra-til)4040
TidsskriftScientific Reports
Udgave nummer1
StatusUdgivet - 8 mar. 2022

Bibliografisk note

© 2022. The Author(s).


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