Reduced levels of pulmonary surfactant in COVID-19 ARDS

Peter Schousboe; Andreas Ronit; Henning B Nielsen; Thomas Benfield; Lothar Wiese; Nikolaos Scoutaris; Henrik Verder; Ronan M G Berg; Povl Verder; Ronni R Plovsing

doi:10.1038/s41598-022-07944-4

Reduced levels of pulmonary surfactant in COVID-19 ARDS

Peter Schousboe^*, Andreas Ronit^*, Henning B Nielsen, Thomas Benfield, Lothar Wiese, Nikolaos Scoutaris, Henrik Verder, Ronan M G Berg, Povl Verder, Ronni R Plovsing

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

To provide novel data on surfactant levels in adult COVID-19 patients, we collected bronchoalveolar lavage fluid less than 72 h after intubation and used Fourier Transform Infrared Spectroscopy to measure levels of dipalmitoylphosphatidylcholine (DPPC). A total of eleven COVID-19 patients with moderate-to-severe ARDS (CARDS) and 15 healthy controls were included. CARDS patients had lower DPPC levels than healthy controls. Moreover, a principal component analysis was able to separate patient groups into distinguishable subgroups. Our findings indicate markedly impaired pulmonary surfactant levels in COVID-19 patients, justifying further studies and clinical trials of exogenous surfactant.

Originalsprog	Engelsk
Sider (fra-til)	4040
Tidsskrift	Scientific Reports
Vol/bind	12
Udgave nummer	1
DOI	https://doi.org/10.1038/s41598-022-07944-4
Status	Udgivet - 8 mar. 2022

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10.1038/s41598-022-07944-4

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8904856/

Citationsformater

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abstract = "To provide novel data on surfactant levels in adult COVID-19 patients, we collected bronchoalveolar lavage fluid less than 72 h after intubation and used Fourier Transform Infrared Spectroscopy to measure levels of dipalmitoylphosphatidylcholine (DPPC). A total of eleven COVID-19 patients with moderate-to-severe ARDS (CARDS) and 15 healthy controls were included. CARDS patients had lower DPPC levels than healthy controls. Moreover, a principal component analysis was able to separate patient groups into distinguishable subgroups. Our findings indicate markedly impaired pulmonary surfactant levels in COVID-19 patients, justifying further studies and clinical trials of exogenous surfactant.",

author = "Peter Schousboe and Andreas Ronit and Nielsen, {Henning B} and Thomas Benfield and Lothar Wiese and Nikolaos Scoutaris and Henrik Verder and Berg, {Ronan M G} and Povl Verder and Plovsing, {Ronni R}",

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AU - Schousboe, Peter

AU - Ronit, Andreas

AU - Nielsen, Henning B

AU - Benfield, Thomas

AU - Wiese, Lothar

AU - Scoutaris, Nikolaos

AU - Verder, Henrik

AU - Berg, Ronan M G

AU - Verder, Povl

AU - Plovsing, Ronni R

PY - 2022/3/8

Y1 - 2022/3/8

N2 - To provide novel data on surfactant levels in adult COVID-19 patients, we collected bronchoalveolar lavage fluid less than 72 h after intubation and used Fourier Transform Infrared Spectroscopy to measure levels of dipalmitoylphosphatidylcholine (DPPC). A total of eleven COVID-19 patients with moderate-to-severe ARDS (CARDS) and 15 healthy controls were included. CARDS patients had lower DPPC levels than healthy controls. Moreover, a principal component analysis was able to separate patient groups into distinguishable subgroups. Our findings indicate markedly impaired pulmonary surfactant levels in COVID-19 patients, justifying further studies and clinical trials of exogenous surfactant.

AB - To provide novel data on surfactant levels in adult COVID-19 patients, we collected bronchoalveolar lavage fluid less than 72 h after intubation and used Fourier Transform Infrared Spectroscopy to measure levels of dipalmitoylphosphatidylcholine (DPPC). A total of eleven COVID-19 patients with moderate-to-severe ARDS (CARDS) and 15 healthy controls were included. CARDS patients had lower DPPC levels than healthy controls. Moreover, a principal component analysis was able to separate patient groups into distinguishable subgroups. Our findings indicate markedly impaired pulmonary surfactant levels in COVID-19 patients, justifying further studies and clinical trials of exogenous surfactant.

U2 - 10.1038/s41598-022-07944-4

DO - 10.1038/s41598-022-07944-4

M3 - Article

C2 - 35260704

SN - 2045-2322

VL - 12

SP - 4040

JO - Scientific Reports

JF - Scientific Reports

IS - 1

ER -

Reduced levels of pulmonary surfactant in COVID-19 ARDS

Abstract

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