TY - JOUR
T1 - Ratio of ST-Segment and myoglobin slopes to estimate myocardial salvage during thrombolytic therapy for acute myocardial infarction
AU - Baskin, Julie M.
AU - Wilkins, Michelle L.
AU - Ohman, E. Magnus
AU - Clemmensen, Peter
AU - Grande, Peer
AU - Christenson, Robert H.
AU - Sevilla, Dorina C.
AU - Wagner, Nancy B.
AU - Wagner, Galen S.
PY - 1993/6/1
Y1 - 1993/6/1
N2 - The use of intravenous thrombolytic therapy to achieve myocardial salvage has become common practice in patients presenting during the early hours of acute myocardial infarction (AMI).1-3 A prompt, noninvasive estimation of salvage would be useful in determining further therapy for each patient. Clinical indexes of salvage should be accurate, easy to perform, inexpensive, and yield rapid results. Standard electrocardiographic and serum biochemical methods have been shown to indicate myocardial reperfusion.4-9 Electrocardiographic ST-segment elevation tends to partially resolve immediately after reperfusion, but only 50% of patients have as much as 50% resolution within 90 minutes.4 Plasma levels of intracellular macromolecules increase early owing to washout through the lymph and blood, but only if irreversible damage has already occurred.5-9 The present study of patients with AMI was designed to observe serial changes in both the ST segments, and serum levels of creatine kinase-MB and myoglobin after angiographically documented reperfusion; it tests the hypothesis that the ratio of ST-segment decrease to serum macromolecular increase can predict salvage of the jeopardized myocardium.
AB - The use of intravenous thrombolytic therapy to achieve myocardial salvage has become common practice in patients presenting during the early hours of acute myocardial infarction (AMI).1-3 A prompt, noninvasive estimation of salvage would be useful in determining further therapy for each patient. Clinical indexes of salvage should be accurate, easy to perform, inexpensive, and yield rapid results. Standard electrocardiographic and serum biochemical methods have been shown to indicate myocardial reperfusion.4-9 Electrocardiographic ST-segment elevation tends to partially resolve immediately after reperfusion, but only 50% of patients have as much as 50% resolution within 90 minutes.4 Plasma levels of intracellular macromolecules increase early owing to washout through the lymph and blood, but only if irreversible damage has already occurred.5-9 The present study of patients with AMI was designed to observe serial changes in both the ST segments, and serum levels of creatine kinase-MB and myoglobin after angiographically documented reperfusion; it tests the hypothesis that the ratio of ST-segment decrease to serum macromolecular increase can predict salvage of the jeopardized myocardium.
UR - http://www.scopus.com/inward/record.url?scp=0027174104&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(93)90557-S
DO - 10.1016/0002-9149(93)90557-S
M3 - Article
C2 - 8498383
AN - SCOPUS:0027174104
SN - 0002-9149
VL - 71
SP - 1362
EP - 1365
JO - The American Journal of Cardiology
JF - The American Journal of Cardiology
IS - 15
ER -