Quinolones for sepsis. A protocol for a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis

Steven Kwasi Korang; Mathias Maagaard; Joshua Feinberg; Anders Perner; Christian Gluud; Janus C Jakobsen

doi:10.1111/aas.13418

Quinolones for sepsis. A protocol for a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis

Steven Kwasi Korang^*, Mathias Maagaard, Joshua Feinberg, Anders Perner, Christian Gluud, Janus C Jakobsen

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Protokol › peer review

Abstract

BACKGROUND: Sepsis is a relatively common and deadly condition that constitutes a major challenge to the modern health care system. Quinolones are sometimes used in combination with beta-lactam antibiotics for sepsis, but no former systematic review has assessed the benefits and harms of quinolones in patients with sepsis.

METHODS: We will perform a systematic review with meta-analysis and trial sequential analysis including randomised clinical trials assessing the effects of quinolones as add on therapy to usual care in children and adults with sepsis. For the assessment of harms, we will also include quasi-randomised studies and observational studies identified during our searches for randomised clinical trials.

DISCUSSION: This systematic review will clarify if there is evidence to support quinolones being part of the standard treatment for sepsis.

Originalsprog	Engelsk
Sider (fra-til)	1113-1123
Antal sider	11
Tidsskrift	Acta Anaesthesiologica Scandinavica
Vol/bind	63
Udgave nummer	8
DOI	https://doi.org/10.1111/aas.13418
Status	Udgivet - sep. 2019

Bibliografisk note

� 2019 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

Adgang til dokumentet

10.1111/aas.13418

Citationsformater

@article{d45a00601c3a49a5aca908cca2430f32,

title = "Quinolones for sepsis. A protocol for a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis",

abstract = "BACKGROUND: Sepsis is a relatively common and deadly condition that constitutes a major challenge to the modern health care system. Quinolones are sometimes used in combination with beta-lactam antibiotics for sepsis, but no former systematic review has assessed the benefits and harms of quinolones in patients with sepsis.METHODS: We will perform a systematic review with meta-analysis and trial sequential analysis including randomised clinical trials assessing the effects of quinolones as add on therapy to usual care in children and adults with sepsis. For the assessment of harms, we will also include quasi-randomised studies and observational studies identified during our searches for randomised clinical trials.DISCUSSION: This systematic review will clarify if there is evidence to support quinolones being part of the standard treatment for sepsis.",

keywords = "Clinical Protocols, Humans, Quinolones/therapeutic use, Sepsis/drug therapy, septic shock, Trial Sequential Analysis, children, adults, quinolones, systematic review, sepsis",

author = "Korang, {Steven Kwasi} and Mathias Maagaard and Joshua Feinberg and Anders Perner and Christian Gluud and Jakobsen, {Janus C}",

note = "� 2019 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.",

year = "2019",

month = sep,

doi = "10.1111/aas.13418",

language = "English",

volume = "63",

pages = "1113--1123",

journal = "Acta Anaesthesiologica Scandinavica",

issn = "0001-5172",

publisher = "Blackwell Munksgaard",

number = "8",

}

TY - JOUR

T1 - Quinolones for sepsis. A protocol for a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis

AU - Korang, Steven Kwasi

AU - Maagaard, Mathias

AU - Feinberg, Joshua

AU - Perner, Anders

AU - Gluud, Christian

AU - Jakobsen, Janus C

N1 - � 2019 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

PY - 2019/9

Y1 - 2019/9

N2 - BACKGROUND: Sepsis is a relatively common and deadly condition that constitutes a major challenge to the modern health care system. Quinolones are sometimes used in combination with beta-lactam antibiotics for sepsis, but no former systematic review has assessed the benefits and harms of quinolones in patients with sepsis.METHODS: We will perform a systematic review with meta-analysis and trial sequential analysis including randomised clinical trials assessing the effects of quinolones as add on therapy to usual care in children and adults with sepsis. For the assessment of harms, we will also include quasi-randomised studies and observational studies identified during our searches for randomised clinical trials.DISCUSSION: This systematic review will clarify if there is evidence to support quinolones being part of the standard treatment for sepsis.

AB - BACKGROUND: Sepsis is a relatively common and deadly condition that constitutes a major challenge to the modern health care system. Quinolones are sometimes used in combination with beta-lactam antibiotics for sepsis, but no former systematic review has assessed the benefits and harms of quinolones in patients with sepsis.METHODS: We will perform a systematic review with meta-analysis and trial sequential analysis including randomised clinical trials assessing the effects of quinolones as add on therapy to usual care in children and adults with sepsis. For the assessment of harms, we will also include quasi-randomised studies and observational studies identified during our searches for randomised clinical trials.DISCUSSION: This systematic review will clarify if there is evidence to support quinolones being part of the standard treatment for sepsis.

KW - Clinical Protocols

KW - Humans

KW - Quinolones/therapeutic use

KW - Sepsis/drug therapy

KW - septic shock

KW - Trial Sequential Analysis

KW - children

KW - adults

KW - quinolones

KW - systematic review

KW - sepsis

U2 - 10.1111/aas.13418

DO - 10.1111/aas.13418

M3 - Protocol

C2 - 31251397

SN - 0001-5172

VL - 63

SP - 1113

EP - 1123

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

IS - 8

ER -

Quinolones for sepsis. A protocol for a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis

Abstract

Bibliografisk note

Adgang til dokumentet

Fingeraftryk

Citationsformater