Quantitative assessment of left ventricular systolic wall thickening using multidetector computed tomography

Thomas S. Kristensen, Klaus F. Kofoed, Daniel V. Møller, Mads Ersbøll, Tobias Kühl, Peter von der Recke, Lars Køber, Michael B. Nielsen, Henning Kelbæk

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    Abstrakt

    Background: Multidetector computed tomography (MDCT) of the heart provides both anatomical and functional information. The objective of this study was to evaluate the accuracy of quantitative assessment of left ventricular contractile function in relation to two-dimensional transthoracic echocardiography (TTE). Materials and methods: Sixty-four patients with known or suspected coronary artery disease underwent ECG-gated 64-slice MDCT and TTE. Regional left ventricular contractile function was measured by percent systolic wall thickening (SWT) in 16 myocardial segments using MDCT, and compared with visual evaluation of wall motion score (WMS) by TTE. Global SWT by MDCT was calculated as the mean SWT of all myocardial segments and compared with wall motion index (WMI) by TTE. Results: Eight hundred and eleven segments (81%) were classified as normokinetic, 142 (14%) as hypokinetic, 41 (4%) as akinetic and 5 (0.5%) as dyskinetic by TTE. A significant inverse linear trend was found between regional SWT by MDCT and WMS by TTE (p < 0.001). Sensitivity and specificity for the identification of regional abnormalities of contractile function were 76% and 78%, respectively. A linear correlation between global SWT by MDCT and WMI by TTE was found (r = -0.8, p < 0.001). Sensitivity and specificity for the identification of WMI > 1.5 using global SWT was 91% and 94%, respectively. Conclusion: Quantification of systolic wall thickening by MDCT provides functional information, which is well correlated to visual assessment of global left ventricular contractile function by TTE.

    OriginalsprogEngelsk
    Sider (fra-til)92-97
    Antal sider6
    TidsskriftEuropean Journal of Radiology
    Vol/bind72
    Udgave nummer1
    DOI
    StatusUdgivet - 1 okt. 2009

    Fingeraftryk Udforsk hvilke forskningsemner 'Quantitative assessment of left ventricular systolic wall thickening using multidetector computed tomography' indeholder.

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