Pulmonary Arterial Enlargement in Well-Treated Persons With Human Immunodeficiency Virus

Andreas D Knudsen, Andreas Ronit, Thomas Kristensen, Magda Teresa Thomsen, Anne-Mette Lebech, Michael Huy Cuong, Per Ejlstrup Sigvardsen, Jørgen Tobias Kühl, Andreas Fuchs, Lars Køber, Jens Lundgren, Jørgen Vestbo, Klaus F Kofoed, Susanne D Nielsen

Publikation: Bidrag til tidsskriftArtikelForskningpeer review


BACKGROUND: Pulmonary artery enlargement is a marker of pulmonary hypertension. We aimed to determine the proportion with pulmonary artery enlargement among well-treated persons with human immunodeficiency virus HIV (PWH) and uninfected controls.

METHODS: PWH with a chest computed tomography were included from the ongoing Copenhagen Comorbidity in HIV Infection (COCOMO) study. Age and sex-matched uninfected controls were recruited from the Copenhagen General Population Study. Pulmonary artery enlargement was defined as a ratio of >1 between the diameter of the main pulmonary artery (at the level of its bifurcation) and the diameter of the ascending aorta.

RESULTS: In total, 900 PWH were included, and 44 (5%) had a pulmonary artery-aorta ratio (PA:A) >1. After adjustment for age, sex, and body mass index, obesity (adjusted odds ratio, 4.33; 95% confidence interval, 1.76-10.65; P = .001) and injection drug use (IDU) (4.90; 1.00-18.46; P = .03) were associated with higher odds of having a PA:A >1, and pulmonary indices and smoking status were not. HIV seropositivity was borderline associated with a PA:A >1 (adjusted odds ratio, 1.89; 95% confidence interval, .92-3.85; P = .08).

CONCLUSIONS: A PA:A >1 was common in PWH. Obesity and IDU were independently associated with this finding and HIV serostatus was borderline associated with it, but HIV-related factors were not. Increased awareness may be appropriate in obese PWH and those with IDU.

Sider (fra-til)94-100
Antal sider7
TidsskriftJournal of Infectious Diseases
Udgave nummer1
StatusUdgivet - 1 jan. 2021


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