Psychiatric comorbidity in childhood onset immune-mediated diseases: a systematic review and meta-analysis

Sabine Jansson*, Mikkel Malham, Vibeke Wewer, Charlotte Ulrikka Rask

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftReviewForskningpeer review


AIM: To estimate psychiatric comorbidity in childhood onset immune-mediated inflammatory diseases (IMID).

METHODS: The PRISMA guidelines were followed, and the protocol was registered at Prospero (ID: CRD42021233890). Literature was searched in PubMed, PsycINFO and Embase. Original papers on prevalence rates of diagnosed psychiatric disorders and/or suicide in paediatric onset inflammatory bowel disease (pIBD), rheumatic diseases (RD) and autoimmune liver diseases were selected. Pooled prevalence rates of psychiatric disorders (grouped according to ICD-10 criteria) within the various IMID were calculated using random-effects meta-analysis. Risk of bias was evaluated by the Newcastle-Ottawa scale.

RESULTS: Twenty-three studies were included; 13 describing psychiatric disorders in pIBD and 10 in RD. Anxiety and mood disorders were mostly investigated with pooled prevalence rates in pIBD of 6% (95% confidence interval (CI): 4%-9%) and 4% (95%CI: 2%-8%), respectively, in register-based studies, and 33% (95%CI: 25%-41%) and 18% (95%CI: 12%-26%), respectively, in studies using psychiatric assessment. In RD, rates were 13% (95%CI: 12%-15%) for anxiety disorders and 20% (95%CI: 15%-26%) for mood disorders based on psychiatric assessment.

CONCLUSION: Anxiety and depression are commonly reported in childhood onset IMID. Physicians should be attentive to mental health problems in these patients as they seem overlooked.

Sider (fra-til)490-499
Antal sider10
TidsskriftActa Paediatrica, International Journal of Paediatrics
Udgave nummer3
Tidlig onlinedato5 jan. 2022
StatusUdgivet - mar. 2022

Bibliografisk note

© 2022 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.


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