TY - JOUR
T1 - Proteinases in bone resorption
T2 - obvious and less obvious roles
AU - Delaissé, J M
AU - Engsig, M T
AU - Everts, V
AU - del Carmen Ovejero, M
AU - Ferreras, M
AU - Lund, L
AU - Vu, T H
AU - Werb, Z
AU - Winding, B
AU - Lochter, A
AU - Karsdal, M A
AU - Troen, T
AU - Kirkegaard, T
AU - Lenhard, T
AU - Heegaard, A M
AU - Neff, L
AU - Baron, R
AU - Foged, N T
PY - 2000/2/15
Y1 - 2000/2/15
N2 - Bone resorption is critical for the development and the maintenance of the skeleton, and improper regulation of bone resorption leads to pathological situations. Proteinases are necessary for this process. In this review, we show that this need of proteinases is not only because they are required for the solubilization of bone matrix, but also because they are key components of the mechanism that determines where and when bone resorption will be initiated. Moreover, there are indications that proteinases may also determine whether resorption will be followed by bone formation. Some of the proteinases involved in these different steps of the resorption processes were recently identified, as for instance cathepsin K, MMP-9 (gelatinase B), and interstitial collagenase. However, there is also increasing evidence showing that the critical proteinase(s) may vary depending on the bone type or on other factors.
AB - Bone resorption is critical for the development and the maintenance of the skeleton, and improper regulation of bone resorption leads to pathological situations. Proteinases are necessary for this process. In this review, we show that this need of proteinases is not only because they are required for the solubilization of bone matrix, but also because they are key components of the mechanism that determines where and when bone resorption will be initiated. Moreover, there are indications that proteinases may also determine whether resorption will be followed by bone formation. Some of the proteinases involved in these different steps of the resorption processes were recently identified, as for instance cathepsin K, MMP-9 (gelatinase B), and interstitial collagenase. However, there is also increasing evidence showing that the critical proteinase(s) may vary depending on the bone type or on other factors.
KW - Bone Diseases/enzymology
KW - Bone Resorption
KW - Endopeptidases/metabolism
KW - Extracellular Matrix/enzymology
KW - Humans
U2 - 10.1016/s0009-8981(99)00230-2
DO - 10.1016/s0009-8981(99)00230-2
M3 - Review
C2 - 10675725
SN - 0009-8981
VL - 291
SP - 223
EP - 234
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
IS - 2
ER -