PROSPECTIVE, RANDOMISED, DOUBLE-BLIND STUDY OF RADIONUCLIDE DETERMINATION OF LEFT-VENTRICULAR EJECTION FRACTION IN ACUTE MYOCARDIAL INFARCTION

Thomas Gj o rup*, Birgit Vestergaard, Henning Kelbaek, Ole Munck, John Godtfredsen

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstract

    In a controlled, randomised, double-blind study to see whether knowledge of left-ventricular ejection fraction (LVEF) could reduce the frequency of left-sided heart failure after acute myocardial infarction, LVEF was determined a few days before hospital discharge in a consecutive series of 60 patients. Subsequently, the patients were randomly assigned to two groups. The cardiologist responsible for their treatment was aware of the LVEF result in group I but not in group II. A month after hospital discharge there was no significant difference in the LVEF between the groups. 2 months after discharge there were no significant differences between the groups in clinical and radiological signs of left-ventricular heart failure or the use of drugs. The cardiologist's clinical estimate of the LVEF and the result of the radionuclide determination were significantly correlated. Thus, the use of LVEF did not change the clinical outcome. The need for randomised controlled studies in the evaluation of diagnostic methods is emphasised.

    OriginalsprogEngelsk
    Sider (fra-til)583-585
    Antal sider3
    TidsskriftThe Lancet
    Vol/bind327
    Udgave nummer8481
    DOI
    StatusUdgivet - 15 mar. 1986

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