Prospective cohort study by InspECT on safety and efficacy of electrochemotherapy for cutaneous tumors and metastases depending on ulceration

Carla Sophie Claussen; Graeme Moir; Falk G Bechara; Antonio Orlando; Paolo Matteucci; David Mowatt; Anthony James P Clover; Matteo Mascherini; Julie Gehl; Tobian Muir; Gregor Sersa; Ales Groselj; Joy Odili; Roberto Giorgione; Luca Giovanni Campana; Giulia Bertino; Pietro Curatolo; Shramana Banerjee; Erika Kis; Pietro Quaglino; Rowan Pritchard-Jones; Francesca De Terlizzi; Eva-Maria Grischke; Christian Kunte

doi:10.1111/ddg.14699

Prospective cohort study by InspECT on safety and efficacy of electrochemotherapy for cutaneous tumors and metastases depending on ulceration

Carla Sophie Claussen, Graeme Moir, Falk G Bechara, Antonio Orlando, Paolo Matteucci, David Mowatt, Anthony James P Clover, Matteo Mascherini, Julie Gehl, Tobian Muir, Gregor Sersa, Ales Groselj, Joy Odili, Roberto Giorgione, Luca Giovanni Campana, Giulia Bertino, Pietro Curatolo, Shramana Banerjee, Erika Kis, Pietro QuaglinoRowan Pritchard-Jones, Francesca De Terlizzi, Eva-Maria Grischke, Christian Kunte^*

^*Corresponding author af dette arbejde

Klinisk Onkologisk Afdeling

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

BACKGROUND: Electrochemotherapy (ECT) is an effective local treatment for cutaneous tumors. The aim of this study was to compare the effectiveness of ECT in ulcerated vs. non-ulcerated tumors and investigate the effect on tumor-associated symptoms.

METHODS: Twenty cancer centers in the International Network for Sharing Practices on Electrochemotherapy (InspECT) prospectively collected data. ECT was performed following ESOPE protocol. Response was evaluated by lesion size development. Pain, symptoms, performance status (ECOG-Index) and health status (EQ-5D questionnaire) were evaluated.

RESULTS: 716 patients with ulcerated (n = 302) and non-ulcerated (n = 414) cutaneous tumors and metastases were included (minimum follow-up of 45 days). Non-ulcerated lesions responded to ECT better than ulcerated lesions (complete response 65 % vs. 51 %, p = 0.0061). Only 38 % (115/302) with ulcerated lesions before ECT presented with ulcerated lesions at final follow-up. Patients with ulcerated lesions reported higher pain and more severe symptoms compared to non-ulcerated lesions, which significantly and continuously improved following ECT. In non-ulcerated lesions however, pain spiked during the treatment. No serious adverse events were reported.

CONCLUSIONS: ECT is a safe and effective local treatment for cutaneous tumors. While ECT improves symptoms especially in patients with ulcerated lesions, data suggest the implementation of a perioperative pain management in non-ulcerated lesions during ECT.

Originalsprog	Engelsk
Sider (fra-til)	470-481
Antal sider	12
Tidsskrift	JDDG - Journal of the German Society of Dermatology
Vol/bind	20
Udgave nummer	4
Tidlig onlinedato	5 apr. 2022
DOI	https://doi.org/10.1111/ddg.14699
Status	Udgivet - apr. 2022

Bibliografisk note

Adgang til dokumentet

10.1111/ddg.14699

Citationsformater

Claussen, C. S., Moir, G., Bechara, F. G., Orlando, A., Matteucci, P., Mowatt, D., Clover, A. J. P., Mascherini, M., Gehl, J., Muir, T., Sersa, G., Groselj, A., Odili, J., Giorgione, R., Campana, L. G., Bertino, G., Curatolo, P., Banerjee, S., Kis, E., ... Kunte, C. (2022). Prospective cohort study by InspECT on safety and efficacy of electrochemotherapy for cutaneous tumors and metastases depending on ulceration. JDDG - Journal of the German Society of Dermatology, 20(4), 470-481. https://doi.org/10.1111/ddg.14699

@article{77b64069e5d046c5b80158fdd09925d8,

title = "Prospective cohort study by InspECT on safety and efficacy of electrochemotherapy for cutaneous tumors and metastases depending on ulceration",

abstract = "BACKGROUND: Electrochemotherapy (ECT) is an effective local treatment for cutaneous tumors. The aim of this study was to compare the effectiveness of ECT in ulcerated vs. non-ulcerated tumors and investigate the effect on tumor-associated symptoms.METHODS: Twenty cancer centers in the International Network for Sharing Practices on Electrochemotherapy (InspECT) prospectively collected data. ECT was performed following ESOPE protocol. Response was evaluated by lesion size development. Pain, symptoms, performance status (ECOG-Index) and health status (EQ-5D questionnaire) were evaluated.RESULTS: 716 patients with ulcerated (n = 302) and non-ulcerated (n = 414) cutaneous tumors and metastases were included (minimum follow-up of 45 days). Non-ulcerated lesions responded to ECT better than ulcerated lesions (complete response 65 % vs. 51 %, p = 0.0061). Only 38 % (115/302) with ulcerated lesions before ECT presented with ulcerated lesions at final follow-up. Patients with ulcerated lesions reported higher pain and more severe symptoms compared to non-ulcerated lesions, which significantly and continuously improved following ECT. In non-ulcerated lesions however, pain spiked during the treatment. No serious adverse events were reported.CONCLUSIONS: ECT is a safe and effective local treatment for cutaneous tumors. While ECT improves symptoms especially in patients with ulcerated lesions, data suggest the implementation of a perioperative pain management in non-ulcerated lesions during ECT.",

author = "Claussen, {Carla Sophie} and Graeme Moir and Bechara, {Falk G} and Antonio Orlando and Paolo Matteucci and David Mowatt and Clover, {Anthony James P} and Matteo Mascherini and Julie Gehl and Tobian Muir and Gregor Sersa and Ales Groselj and Joy Odili and Roberto Giorgione and Campana, {Luca Giovanni} and Giulia Bertino and Pietro Curatolo and Shramana Banerjee and Erika Kis and Pietro Quaglino and Rowan Pritchard-Jones and {De Terlizzi}, Francesca and Eva-Maria Grischke and Christian Kunte",

note = "{\textcopyright} 2022 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.",

year = "2022",

month = apr,

doi = "10.1111/ddg.14699",

language = "English",

volume = "20",

pages = "470--481",

journal = "JDDG - Journal of the German Society of Dermatology",

issn = "1610-0379",

publisher = "Wiley-Blackwell",

number = "4",

}

Claussen, CS, Moir, G, Bechara, FG, Orlando, A, Matteucci, P, Mowatt, D, Clover, AJP, Mascherini, M, Gehl, J, Muir, T, Sersa, G, Groselj, A, Odili, J, Giorgione, R, Campana, LG, Bertino, G, Curatolo, P, Banerjee, S, Kis, E, Quaglino, P, Pritchard-Jones, R, De Terlizzi, F, Grischke, E-M & Kunte, C 2022, 'Prospective cohort study by InspECT on safety and efficacy of electrochemotherapy for cutaneous tumors and metastases depending on ulceration', JDDG - Journal of the German Society of Dermatology, bind 20, nr. 4, s. 470-481. https://doi.org/10.1111/ddg.14699

Prospective cohort study by InspECT on safety and efficacy of electrochemotherapy for cutaneous tumors and metastases depending on ulceration. / Claussen, Carla Sophie; Moir, Graeme; Bechara, Falk G et al.

I: JDDG - Journal of the German Society of Dermatology, Bind 20, Nr. 4, 04.2022, s. 470-481.

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

TY - JOUR

T1 - Prospective cohort study by InspECT on safety and efficacy of electrochemotherapy for cutaneous tumors and metastases depending on ulceration

AU - Claussen, Carla Sophie

AU - Moir, Graeme

AU - Bechara, Falk G

AU - Orlando, Antonio

AU - Matteucci, Paolo

AU - Mowatt, David

AU - Clover, Anthony James P

AU - Mascherini, Matteo

AU - Gehl, Julie

AU - Muir, Tobian

AU - Sersa, Gregor

AU - Groselj, Ales

AU - Odili, Joy

AU - Giorgione, Roberto

AU - Campana, Luca Giovanni

AU - Bertino, Giulia

AU - Curatolo, Pietro

AU - Banerjee, Shramana

AU - Kis, Erika

AU - Quaglino, Pietro

AU - Pritchard-Jones, Rowan

AU - De Terlizzi, Francesca

AU - Grischke, Eva-Maria

AU - Kunte, Christian

PY - 2022/4

Y1 - 2022/4

N2 - BACKGROUND: Electrochemotherapy (ECT) is an effective local treatment for cutaneous tumors. The aim of this study was to compare the effectiveness of ECT in ulcerated vs. non-ulcerated tumors and investigate the effect on tumor-associated symptoms.METHODS: Twenty cancer centers in the International Network for Sharing Practices on Electrochemotherapy (InspECT) prospectively collected data. ECT was performed following ESOPE protocol. Response was evaluated by lesion size development. Pain, symptoms, performance status (ECOG-Index) and health status (EQ-5D questionnaire) were evaluated.RESULTS: 716 patients with ulcerated (n = 302) and non-ulcerated (n = 414) cutaneous tumors and metastases were included (minimum follow-up of 45 days). Non-ulcerated lesions responded to ECT better than ulcerated lesions (complete response 65 % vs. 51 %, p = 0.0061). Only 38 % (115/302) with ulcerated lesions before ECT presented with ulcerated lesions at final follow-up. Patients with ulcerated lesions reported higher pain and more severe symptoms compared to non-ulcerated lesions, which significantly and continuously improved following ECT. In non-ulcerated lesions however, pain spiked during the treatment. No serious adverse events were reported.CONCLUSIONS: ECT is a safe and effective local treatment for cutaneous tumors. While ECT improves symptoms especially in patients with ulcerated lesions, data suggest the implementation of a perioperative pain management in non-ulcerated lesions during ECT.

AB - BACKGROUND: Electrochemotherapy (ECT) is an effective local treatment for cutaneous tumors. The aim of this study was to compare the effectiveness of ECT in ulcerated vs. non-ulcerated tumors and investigate the effect on tumor-associated symptoms.METHODS: Twenty cancer centers in the International Network for Sharing Practices on Electrochemotherapy (InspECT) prospectively collected data. ECT was performed following ESOPE protocol. Response was evaluated by lesion size development. Pain, symptoms, performance status (ECOG-Index) and health status (EQ-5D questionnaire) were evaluated.RESULTS: 716 patients with ulcerated (n = 302) and non-ulcerated (n = 414) cutaneous tumors and metastases were included (minimum follow-up of 45 days). Non-ulcerated lesions responded to ECT better than ulcerated lesions (complete response 65 % vs. 51 %, p = 0.0061). Only 38 % (115/302) with ulcerated lesions before ECT presented with ulcerated lesions at final follow-up. Patients with ulcerated lesions reported higher pain and more severe symptoms compared to non-ulcerated lesions, which significantly and continuously improved following ECT. In non-ulcerated lesions however, pain spiked during the treatment. No serious adverse events were reported.CONCLUSIONS: ECT is a safe and effective local treatment for cutaneous tumors. While ECT improves symptoms especially in patients with ulcerated lesions, data suggest the implementation of a perioperative pain management in non-ulcerated lesions during ECT.

U2 - 10.1111/ddg.14699

DO - 10.1111/ddg.14699

M3 - Article

C2 - 35384261

SN - 1610-0379

VL - 20

SP - 470

EP - 481

JO - JDDG - Journal of the German Society of Dermatology

JF - JDDG - Journal of the German Society of Dermatology

IS - 4

ER -

Prospective cohort study by InspECT on safety and efficacy of electrochemotherapy for cutaneous tumors and metastases depending on ulceration

Abstract

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