Proof of concept of triple COMBI therapy to prohibit MPN progression to AML

Hans Carl Hasselbalch; Vibe Skov; Lasse Kjaer; Morten Kranker Larsen

doi:10.1111/bjh.19173

Proof of concept of triple COMBI therapy to prohibit MPN progression to AML

Hans Carl Hasselbalch^*, Vibe Skov, Lasse Kjaer, Morten Kranker Larsen

^*Corresponding author af dette arbejde

Hæmatologisk Afdeling

Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning

Abstract

Patients with accelerated or blast phase myeloproliferative neoplasms have a dismal prognosis. The report by de Castro et al. provides important information on the rationale and prospect for a novel therapeutic approach combining interferon-alpha2 with 5-azacytidine and a JAK1-2 inhibitor (ruxolitinib) to be explored in well-designed clinical trials. Commentary on: Castro et al. Ratio of stemness to interferon signalling as a biomarker and therapeutic target of myeloproliferative neoplasm progression to acute myeloid leukaemia. Br J Haematol 2024;204:206-220.

Originalsprog	Engelsk
Sider (fra-til)	16-18
Antal sider	3
Tidsskrift	British Journal of Haematology
Vol/bind	204
Udgave nummer	1
Tidlig onlinedato	13 nov. 2023
DOI	https://doi.org/10.1111/bjh.19173
Status	Udgivet - jan. 2024

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10.1111/bjh.19173Licens: CC BY-NC

Citationsformater

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title = "Proof of concept of triple COMBI therapy to prohibit MPN progression to AML",

abstract = "Patients with accelerated or blast phase myeloproliferative neoplasms have a dismal prognosis. The report by de Castro et al. provides important information on the rationale and prospect for a novel therapeutic approach combining interferon-alpha2 with 5-azacytidine and a JAK1-2 inhibitor (ruxolitinib) to be explored in well-designed clinical trials. Commentary on: Castro et al. Ratio of stemness to interferon signalling as a biomarker and therapeutic target of myeloproliferative neoplasm progression to acute myeloid leukaemia. Br J Haematol 2024;204:206-220.",

keywords = "Azacitidine/therapeutic use, Humans, Interferons/therapeutic use, Leukemia, Myeloid, Acute/drug therapy, Myeloproliferative Disorders/drug therapy, Prognosis",

author = "Hasselbalch, {Hans Carl} and Vibe Skov and Lasse Kjaer and Larsen, {Morten Kranker}",

note = "{\textcopyright} 2023 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.",

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doi = "10.1111/bjh.19173",

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AU - Hasselbalch, Hans Carl

AU - Skov, Vibe

AU - Kjaer, Lasse

AU - Larsen, Morten Kranker

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N2 - Patients with accelerated or blast phase myeloproliferative neoplasms have a dismal prognosis. The report by de Castro et al. provides important information on the rationale and prospect for a novel therapeutic approach combining interferon-alpha2 with 5-azacytidine and a JAK1-2 inhibitor (ruxolitinib) to be explored in well-designed clinical trials. Commentary on: Castro et al. Ratio of stemness to interferon signalling as a biomarker and therapeutic target of myeloproliferative neoplasm progression to acute myeloid leukaemia. Br J Haematol 2024;204:206-220.

AB - Patients with accelerated or blast phase myeloproliferative neoplasms have a dismal prognosis. The report by de Castro et al. provides important information on the rationale and prospect for a novel therapeutic approach combining interferon-alpha2 with 5-azacytidine and a JAK1-2 inhibitor (ruxolitinib) to be explored in well-designed clinical trials. Commentary on: Castro et al. Ratio of stemness to interferon signalling as a biomarker and therapeutic target of myeloproliferative neoplasm progression to acute myeloid leukaemia. Br J Haematol 2024;204:206-220.

KW - Azacitidine/therapeutic use

KW - Humans

KW - Interferons/therapeutic use

KW - Leukemia, Myeloid, Acute/drug therapy

KW - Myeloproliferative Disorders/drug therapy

KW - Prognosis

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DO - 10.1111/bjh.19173

M3 - Comment/debate

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SN - 0007-1048

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SP - 16

EP - 18

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 1

ER -

Proof of concept of triple COMBI therapy to prohibit MPN progression to AML

Abstract

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