TY - JOUR
T1 - Prokinetic agents in adult intensive care unit patients (PATIENCE)-An international inception cohort study protocol
AU - Crone, Vera
AU - Møller, Morten Hylander
AU - Perner, Anders
AU - Alhazzani, Waleed
AU - Granholm, Anders
AU - Krogsgaard, Laura Rindom
AU - Al-Fares, Abdulrahman
AU - Hästbacka, Johanna
AU - Ostermann, Marlies
AU - Pfortmueller, Carmen A
AU - Ferrer, Richard
AU - Blaser, Annika Reintam
AU - Sigurdsson, Martin I
AU - Wall, Olof
AU - Keus, Eric
AU - Szczeklik, Wojciech
AU - Krag, Mette
N1 - © 2024 The Author(s). Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.
PY - 2024/11
Y1 - 2024/11
N2 - BACKGROUND: Feeding intolerance is common in critically ill patients and can lead to malnutrition. Prokinetic agents may be used to enhance the uptake of nutrition. However, the evidence on the effectiveness and safety of prokinetic agents is sparse, and there is a lack of data on their use in intensive care units (ICU).METHODS: We will conduct an international 14-day inception cohort study of 1000 acutely admitted adult ICU patients. Data will be collected from ICU admission and daily during ICU stay for up to 90 days. The primary outcome will be the proportion of ICU patients who receive prokinetic agents. Secondary outcomes include mortality, days alive without life support, days alive out of ICU, days alive out of hospital (all within 90 days) and the number of patients with one or more serious adverse events.RESULTS: We will present data on the use of prokinetic agents descriptively and use Cox regressions with death and ICU discharge as competing events to evaluate the association between patient characteristics and the use of prokinetic agents. We will use extended Cox models with time-varying covariates and linear regression models to assess the associations between the use of prokinetic agents and the secondary outcomes.CONCLUSION: The outlined international cohort study will provide valuable epidemiological data on the use of prokinetic agents in adult, acutely admitted ICU patients.
AB - BACKGROUND: Feeding intolerance is common in critically ill patients and can lead to malnutrition. Prokinetic agents may be used to enhance the uptake of nutrition. However, the evidence on the effectiveness and safety of prokinetic agents is sparse, and there is a lack of data on their use in intensive care units (ICU).METHODS: We will conduct an international 14-day inception cohort study of 1000 acutely admitted adult ICU patients. Data will be collected from ICU admission and daily during ICU stay for up to 90 days. The primary outcome will be the proportion of ICU patients who receive prokinetic agents. Secondary outcomes include mortality, days alive without life support, days alive out of ICU, days alive out of hospital (all within 90 days) and the number of patients with one or more serious adverse events.RESULTS: We will present data on the use of prokinetic agents descriptively and use Cox regressions with death and ICU discharge as competing events to evaluate the association between patient characteristics and the use of prokinetic agents. We will use extended Cox models with time-varying covariates and linear regression models to assess the associations between the use of prokinetic agents and the secondary outcomes.CONCLUSION: The outlined international cohort study will provide valuable epidemiological data on the use of prokinetic agents in adult, acutely admitted ICU patients.
KW - Adult
KW - Cohort Studies
KW - Critical Care/methods
KW - Critical Illness
KW - Gastrointestinal Agents/therapeutic use
KW - Humans
KW - Intensive Care Units
U2 - 10.1111/aas.14534
DO - 10.1111/aas.14534
M3 - Protocol
C2 - 39350471
SN - 0001-5172
VL - 68
SP - 1601
EP - 1606
JO - Acta Anaesthesiologica Scandinavica
JF - Acta Anaesthesiologica Scandinavica
IS - 10
ER -