Prognostic significance of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in primary breast cancer

A. Knoop, P. A. Andreasen, J. A. Andersen, S. Hansen, A. V. Lænkholm, A. C.W. Simonsen, J. Andersen, J. Overgaard, C. Rose

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    Abstrakt

    The uPA-mediated pathway of plasminogen activation is central to cancer metastasis. Whether uPA and PAI-1 are related to local recurrence, metastatic spread or both is not clear. We present a retrospective study of 429 primary breast cancer patients with a median followup of 5.1 years, in which the levels of uPA and PAI-1 in tumour extracts were analysed by means of an enzyme-linked immunosorbent assay. The median values of uPA and PAI-1, which were used as cut-off points, were 4.5 and 11.1 ng mg-1 protein respectively. The levels of uPA and PAI-1 were correlated with tumour size, degree of anaplasia, steroid receptor status and number of positive nodes. Patients with high content of either uUPA or PAI-1 had increased risk of relapse and death. We demonstrated an independent ability of PAI-1 to predict distant metastasis (relative risk 1.7, confidence limits 1.22 and 2.46) and that neither uPA nor PAI-1 provided any information regarding local recurrence.

    OriginalsprogEngelsk
    Sider (fra-til)932-940
    Antal sider9
    TidsskriftBritish Journal of Cancer
    Vol/bind77
    Udgave nummer6
    DOI
    StatusUdgivet - 1 jan. 1998

    Fingeraftryk Udforsk hvilke forskningsemner 'Prognostic significance of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in primary breast cancer' indeholder.

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