Prognostic impact of tumor MET expression among patients with stage IV gastric cancer: a Danish cohort study

Rune Erichsen, Michael A. Kelsh, Kelly S. Oliner, Karsten B. Nielsen, Trine Frøslev, Anne Vibeke Lænkholm, Mogens Vyberg, John Acquavella, Henrik Toft Sørensen

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstrakt

Purpose We aimed to investigate the prevalence and prognostic impact of tumor mesenchymal epithelial transition factor (MET) expression in stage IV gastric cancers in a real-world clinical setting because existing evidence is sparse. Methods The study included archived cancer specimens from 103 stage IV gastric cancer patients (2003–2010). We analyzed MET-protein expression by immunohistochemistry (MET-positive if ≥25% of tumor cells showed MET expression). We calculated overall survival using the Kaplan–Meier method and hazard ratios comparing mortality among MET-positive and MET-negative patients using Cox regression adjusted for age, gender, and comorbidity. Results We found that 62.1% (95% confidence interval, 52.0–71.5) of patients had MET-positive tumors. Median survival was lower among patients with MET-positive tumors (3.5 months) than among patients with MET-negative tumors (9.6 months), corresponding to an adjusted hazard ratio of 2.2 (95% confidence interval, 1.3–3.7). Conclusions Tumor MET expression is prevalent and has substantial prognostic impact in stage IV gastric cancer patients.

OriginalsprogEngelsk
Sider (fra-til)500-503
Antal sider4
TidsskriftAnnals of Epidemiology
Vol/bind26
Udgave nummer7
DOI
StatusUdgivet - jul. 2016

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