Prognostic impact of nodal involvement in Waldenström macroglobulinaemia

Simon Østergaard; Lars Munksgaard; Troels Hammer; Mette Ø Pedersen; Torsten H Nielsen; Lise Mette R Gjerdrum

doi:10.1111/bjh.19809

Prognostic impact of nodal involvement in Waldenström macroglobulinaemia

Simon Østergaard^*, Lars Munksgaard, Troels Hammer, Mette Ø Pedersen, Torsten H Nielsen, Lise Mette R Gjerdrum

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Letter › Forskning › peer review

Abstract

The clinical and prognostic implications of nodal involvement (NI) in Waldenström macroglobulinaemia (WM) are largely unknown. In this study, we explored the impact of NI on clinical presentation and outcome in a population-based cohort of 469 patients with WM, consecutively diagnosed between 2000 and 2022. NI was detected in 34% of patients and was associated with symptomatic disease, adverse prognostic factors, an increased risk of transformation, and lymphoma-related death. Our findings indicate that NI is of prognostic significance in WM, suggesting a need for enhanced surveillance in these patients.

Originalsprog	Engelsk
Sider (fra-til)	2282-2286
Antal sider	5
Tidsskrift	British Journal of Haematology
Vol/bind	205
Udgave nummer	6
Tidlig onlinedato	1 okt. 2024
DOI	https://doi.org/10.1111/bjh.19809
Status	Udgivet - dec. 2024

Bibliografisk note

Adgang til dokumentet

10.1111/bjh.19809Licens: CC BY-NC-ND

Citationsformater

@article{c8a629d3c9ba4047a63cbaa102a2850d,

title = "Prognostic impact of nodal involvement in Waldenstr{\"o}m macroglobulinaemia",

abstract = "The clinical and prognostic implications of nodal involvement (NI) in Waldenstr{\"o}m macroglobulinaemia (WM) are largely unknown. In this study, we explored the impact of NI on clinical presentation and outcome in a population-based cohort of 469 patients with WM, consecutively diagnosed between 2000 and 2022. NI was detected in 34% of patients and was associated with symptomatic disease, adverse prognostic factors, an increased risk of transformation, and lymphoma-related death. Our findings indicate that NI is of prognostic significance in WM, suggesting a need for enhanced surveillance in these patients.",

keywords = "Adult, Aged, Aged, 80 and over, Female, Humans, Lymph Nodes/pathology, Male, Middle Aged, Prognosis, Waldenstrom Macroglobulinemia/mortality",

author = "Simon {\O}stergaard and Lars Munksgaard and Troels Hammer and Pedersen, {Mette {\O}} and Nielsen, {Torsten H} and Gjerdrum, {Lise Mette R}",

note = "{\textcopyright} 2024 The Author(s). British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.",

year = "2024",

month = dec,

doi = "10.1111/bjh.19809",

language = "English",

volume = "205",

pages = "2282--2286",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "John Wiley & Sons Inc.",

number = "6",

}

TY - JOUR

T1 - Prognostic impact of nodal involvement in Waldenström macroglobulinaemia

AU - Østergaard, Simon

AU - Munksgaard, Lars

AU - Hammer, Troels

AU - Pedersen, Mette Ø

AU - Nielsen, Torsten H

AU - Gjerdrum, Lise Mette R

PY - 2024/12

Y1 - 2024/12

N2 - The clinical and prognostic implications of nodal involvement (NI) in Waldenström macroglobulinaemia (WM) are largely unknown. In this study, we explored the impact of NI on clinical presentation and outcome in a population-based cohort of 469 patients with WM, consecutively diagnosed between 2000 and 2022. NI was detected in 34% of patients and was associated with symptomatic disease, adverse prognostic factors, an increased risk of transformation, and lymphoma-related death. Our findings indicate that NI is of prognostic significance in WM, suggesting a need for enhanced surveillance in these patients.

AB - The clinical and prognostic implications of nodal involvement (NI) in Waldenström macroglobulinaemia (WM) are largely unknown. In this study, we explored the impact of NI on clinical presentation and outcome in a population-based cohort of 469 patients with WM, consecutively diagnosed between 2000 and 2022. NI was detected in 34% of patients and was associated with symptomatic disease, adverse prognostic factors, an increased risk of transformation, and lymphoma-related death. Our findings indicate that NI is of prognostic significance in WM, suggesting a need for enhanced surveillance in these patients.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Female

KW - Humans

KW - Lymph Nodes/pathology

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Waldenstrom Macroglobulinemia/mortality

U2 - 10.1111/bjh.19809

DO - 10.1111/bjh.19809

M3 - Letter

C2 - 39350605

SN - 0007-1048

VL - 205

SP - 2282

EP - 2286

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 6

ER -

Prognostic impact of nodal involvement in Waldenström macroglobulinaemia

Abstract

Bibliografisk note

Adgang til dokumentet

Fingeraftryk

Citationsformater