TY - JOUR
T1 - Primary peritoneal carcinoma
T2 - A rare neoplasm with pleomorphic trophoblastic morphology. Case report
AU - Madsen, Charlotte Winther
AU - Hasselby, Jane Preuss
AU - Larsen, Lise Grupe
PY - 2006/7
Y1 - 2006/7
N2 - We report a case of primary peritoneal carcinoma with trophoblastic morphology in a 78-year-old woman, diagnosed by histological and immunohistochemical analysis of surgically resected specimens, including the omentum and part of the small bowel. Microscopically, the resected specimens showed diffuse infiltration of a poorly differentiated tumor. Numerous large, often multinucleated cells were seen, and mitotic figures were frequent. Immunohistochemical staining showed a positive reaction for most cytokeratins, EP4, EMA, CA-125, Glut1, WT1, β-hCG and PLAP. We reached a diagnosis of primary peritoneal carcinoma with trophoblastic morphology. To our knowledge this morphology of a primary peritoneal carcinoma has not been described previously.
AB - We report a case of primary peritoneal carcinoma with trophoblastic morphology in a 78-year-old woman, diagnosed by histological and immunohistochemical analysis of surgically resected specimens, including the omentum and part of the small bowel. Microscopically, the resected specimens showed diffuse infiltration of a poorly differentiated tumor. Numerous large, often multinucleated cells were seen, and mitotic figures were frequent. Immunohistochemical staining showed a positive reaction for most cytokeratins, EP4, EMA, CA-125, Glut1, WT1, β-hCG and PLAP. We reached a diagnosis of primary peritoneal carcinoma with trophoblastic morphology. To our knowledge this morphology of a primary peritoneal carcinoma has not been described previously.
KW - Carcinoma
KW - Human chorionic gonadotropin
KW - Immunohistochemistry
KW - Peritoneum
KW - Trophoblastic
UR - http://www.scopus.com/inward/record.url?scp=33747394354&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0463.2006.apm_293.x
DO - 10.1111/j.1600-0463.2006.apm_293.x
M3 - Article
C2 - 16907865
AN - SCOPUS:33747394354
SN - 0903-4641
VL - 114
SP - 574
EP - 579
JO - APMIS
JF - APMIS
IS - 7-8
ER -