Primary (AL) amyloidosis with gastrointestinal involvement

Lone Galmstrup Madsen, Peter Gimsing, Frank V. Schiødt

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    Objective. Immunoglobulin light-chain (AL) amyloidosis is a rare disease that can affect several organs. The aim of this study was to characterize patients with gastrointestinal manifestations of AL amyloidosis, in terms of symptoms, biochemistry, and outcome. Material and methods. Retrospectively, patients with AL amyloidosis admitted for evaluation of malabsorption in a Department of Gastroenterology between January 2000 and December 2006 were identified. Results. A total of 11 patients (4 F, age 60 years, median (range) 50-69) were included in the study. Gastrointestinal amyloidosis was histologically verified in all patients. All patients had gastrointestinal symptoms, 8 of them prior to establishment of diagnosis. Median (range) delay from initial symptoms to diagnosis was 7 (0-24) months. The most prominent symptom was weight loss (n=10) averaging 7 (0-25) kg, followed by diarrhea (n=5). Steatorrhea (2 mild, 1 moderate, 1 severe) was found in 4 of 7 patients examined. At presentation, 9 patients had hypoalbuminemia and 6 patients had anemia. Three patients were treated with home parenteral nutrition. Five patients received conventional chemotherapy (oral melphalan and prednisone) and 5 patients underwent high-dose melphalan and autologous stem-cell transplantation. Five patients died within the observation period, at a median of 10 (3-36) months after the diagnosis was established. Non-survivors tended to have lower albumin levels on admission and more involvement of other organs compared to survivors. Conclusions. Most patients with gastrointestinal AL amyloidosis experience weight loss and all have signs of malabsorption. Despite treatment the prognosis is grave.

    OriginalsprogEngelsk
    Sider (fra-til)708-711
    Antal sider4
    TidsskriftScandinavian journal of gastroenterology
    Vol/bind44
    Udgave nummer6
    DOI
    StatusUdgivet - 1 jun. 2009

    Fingeraftryk Udforsk hvilke forskningsemner 'Primary (AL) amyloidosis with gastrointestinal involvement' indeholder.

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