Prevalence and socio-demographic characteristics of persons who have never had a headache among healthy voluntary blood donors - a population-based study

Isa Amalie Olofsson, Lisette Kogelman, Andreas Rasmussen, Christian Erikstrup, Erik Sørensen, Helene M Paarup, Henrik Hjalmgrim, Karina Banasik, Kaspar René Nielsen, Kristoffer Soelvsten Burgdorf, Ole Birger Vesterager Pedersen, Henrik Ullum, Jes Olesen, Thomas Folkmann Hansen

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstract

INTRODUCTION: Headache is an extremely prevalent disorder with a lifetime prevalence of 90-99%. However, a small fraction of people never experiences a headache. Research on people without headache could uncover protective factors in headache, but to our knowledge no study on headache-free individuals has been published. We aim to estimate the prevalence of headache-free individuals among Danish blood donors, and to describe the socio-demographics and health factors of headache-free participants.

MATERIALS AND METHODS: In all, 38,557 healthy volunteers were recruited as part of the Danish Blood Donor Study. Headache-free participants were identified based on the question "Have you ever experienced a headache of any kind?". Utilising the Danish registries and self-reported questionnaires, we analysed socio-demographic and lifestyle factors using logistic regression adjusted for age and sex.

RESULTS: The prevalence of headache-free individuals was 4.1% (n = 1362) with a female-male ratio of 1:2.2. To be headache free was significantly associated with an employment status as a student, a low level of income and a regular alcohol consumption.

DISCUSSION: The prevalence of headache-free individuals was comparable to population-wide studies of headache. To be headache free was not associated with a high socio-economic status. Further studies on people without headache will hopefully reveal protective factors in headache, and this novel approach might be useful in other very prevalent disorders.

OriginalsprogEngelsk
Sider (fra-til)1055-1062
Antal sider8
TidsskriftCephalalgia
Vol/bind40
Udgave nummer10
Tidlig onlinedato20 apr. 2020
DOI
StatusUdgivet - sep. 2020

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