Preoperative treatment with oestradiol in women scheduled for vaginal operation for genital prolapse. A randomised, double-blind trial

Christine Felding*, Anne Lis Mikkelsen, Helle V. Clausen, Anne Loft, Lise Grupe Larsen

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstract

    Objective - To disclose a clinical and histopathological effect of local low-dose oestradiol treatment on the vagina. Design - A randomised, double-blind trial. Setting - Two gynaecological departments at University Hospitals. Subjects - Forty-eight postmenopausal women scheduled for surgery because of genital prolapse. Intervention - 25μg oestradiol or placebo, administered as vaginal pessaries daily, 3 weeks prior to surgery. Main outcome measures - Cytological, histological and clinical changes of the vaginal mucosa. Results - The thickness of the vaginal wall increased as did the oestrogenic index. No clinical effect was seen apart from decreased incidence of recurrent cystitis postoperatively. Conclusions - Preoperative oestrogen treatment has been shown to reduce the incidence of recurrent cystitis and may be needed for stimulation of vaginal mucosa; the short-term clinical effect is not convincing, however.

    OriginalsprogEngelsk
    Sider (fra-til)241-249
    Antal sider9
    TidsskriftMaturitas
    Vol/bind15
    Udgave nummer3
    DOI
    StatusUdgivet - dec. 1992

    Fingeraftryk

    Udforsk hvilke forskningsemner 'Preoperative treatment with oestradiol in women scheduled for vaginal operation for genital prolapse. A randomised, double-blind trial' indeholder.

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