Prenatal detection of congenital heart disease in a low risk population undergoing first and second trimester screening

Ditte E.S. Jørgensen*, Niels Vejlstrup, Connie Jørgensen, Lisa Leth Maroun, Jesper Steensberg, Anette Hessellund, Finn Stener Jørgensen, Torben Larsen, Anne Cathrine Shalmi, Lillian Skibsted, Helle Zingenberg, Charlotte Ekelund, Ann Tabor

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstrakt

Objectives: The prenatal detection rate of congenital heart disease (CHD) is low compared with other fetal malformations. Our aim was to evaluate the prenatal detection of CHD in Eastern Denmark. Methods: Fetuses and infants diagnosed with CHD in the period 01.01.2008-31.12.2010 were assessed regarding prenatal detection rate and accuracy, as well as correlation with nuchal translucency (NT) thickness. Results: Out of 86121 infants, 831 were born with CHD (0.96%). The prenatal detection rate of 'all CHD' was 21.3%, of 'Major CHD' 47.4%. Full agreement between prenatal and postnatal/autopsy findings was found in 96% of prenatally detected diagnoses. An NT thickness >95th percentile was found in 15.0% fetuses with 'Major CHD'. Of 'Major CHDs' detected prenatally, 77% were picked up at the time of the malformation scan at weeks 18-21. Conclusions: Nearly half of 'Major CHDs' were detected prenatally. The prenatal cardiac diagnoses showed a high degree of accuracy. Increased NT thickness as a screening tool for CHD performed moderately but is an important high risk group for specialist examination. A minority of the prenatally detected CHDs was identified because of extra scans performed in high risk pregnancies.

OriginalsprogEngelsk
Sider (fra-til)325-330
Antal sider6
TidsskriftPrenatal Diagnosis
Vol/bind35
Udgave nummer4
DOI
StatusUdgivet - 1 apr. 2015

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